ZAP70 Antikörper (N-Term)
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- Target Alle ZAP70 Antikörper anzeigen
- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ZAP70 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- MRKKQIDVAI KVLKQGTEKA DTEEMMREAQ IMHQLDNPYI VRLIGVCQAE
- Homologie
- Cow: 79%, Guinea Pig: 79%, Human: 100%, Mouse: 86%, Rat: 79%
- Produktmerkmale
- This is a rabbit polyclonal antibody against ZAP70. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human ZAP70
- Top Product
- Discover our top product ZAP70 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 312 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
- Andere Bezeichnung
- ZAP70 (ZAP70 Produkte)
- Synonyme
- SRK antikoerper, STCD antikoerper, STD antikoerper, TZK antikoerper, ZAP-70 antikoerper, 70kDa antikoerper, AI327364 antikoerper, Srk antikoerper, mrtle antikoerper, mur antikoerper, zap70 antikoerper, MGC80670 antikoerper, MGC88962 antikoerper, ZAP70 antikoerper, zgc:110383 antikoerper, zeta chain of T-cell receptor associated protein kinase 70 antikoerper, putative tyrosine-protein kinase zap-70 antikoerper, zeta-chain (TCR) associated protein kinase antikoerper, zeta chain of T cell receptor associated protein kinase 70 antikoerper, zeta-chain (TCR) associated protein kinase 70kDa antikoerper, zeta chain of T cell receptor associated protein kinase 70kDa L homeolog antikoerper, zeta chain of T cell receptor associated protein kinase 70kDa antikoerper, tyrosine-protein kinase ZAP-70 antikoerper, ZAP70 antikoerper, Smp_149470 antikoerper, Zap70 antikoerper, zap70.L antikoerper, zap70 antikoerper, LOC707555 antikoerper, LOC100342021 antikoerper, LOC100390922 antikoerper, LOC100542877 antikoerper
- Hintergrund
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This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Alias Symbols: FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Protein Interaction Partner: UBC, CSK, PLCG1, ZAP70, CD247, CD3E, LAT, NDUFB8, ERBB3, EGFR, ANAPC11, ASB3, PTPN22, NR0B2, SHC1, GRB2, APP, LCK, CBL, CBLC, LCP2, CBLB, PIK3R1, CD38, HSPA4, TUBB, TUBA1A, VAV1, TUBA1B, tat, NFAM1, DEF6, ACP1, LAX1, FCRL3, PTPN3, DBNL, CARD11, SLA2, SLAM
Protein Size: 312 - Molekulargewicht
- 34 kDa
- Gen-ID
- 7535
- NCBI Accession
- NM_207519, NP_997402
- UniProt
- P43403
- Pathways
- T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway
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