MRGPRX1 Antikörper (C-Term)

Produktnummer ABIN2788263

Produktdetails anti-MRGPRX1 Antikörper

Target: MRGPRX1 (MAS-Related GPR, Member X1 (MRGPRX1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MRGPRX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FLSALNSSAN PIIYFFVGSF RQRQNRQNLK LVLQRALQDA SEVDEGGGQL

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MRGPRX1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MRGPRX1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 322 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MRGPRX1

Target: MRGPRX1 (MAS-Related GPR, Member X1 (MRGPRX1))

Andere Bezeichnung: MRGPRX1 (MRGPRX1 Produkte)

Synonyme: GPCR antikoerper, MRGX1 antikoerper, SNSR4 antikoerper, MrgC11 antikoerper, Mrgprc11 antikoerper, Snsr1 antikoerper, MAS related GPR family member X1 antikoerper, MAS-related GPR, member X1 antikoerper, MRGPRX1 antikoerper, Mrgprx1 antikoerper

Hintergrund: MRGPRX1 is an orphan receptor. MRGPRX1 is probably involved in the function of nociceptive neurons. It may regulate nociceptor function and/or development, including the sensation or modulation of pain. MRGPRX1 is potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. MRGPRX1 is activated by the antimalarial drug, chloroquine and may mediate chloroquine-induced itch, in an histamine-independent manner.
Alias Symbols: GPCR, MRGX1, SNSR4
Protein Interaction Partner: GNG2, GNB1, GNAQ, GNAI2,
Protein Size: 322

Molekulargewicht: 36 kDa

Gen-ID: 259249

NCBI Accession: NM_147199, NP_671732

UniProt: Q96LB2