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GCH1 Antikörper (C-Term)

GCH1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd, Meerschweinchen, Saccharomyces cerevisiae, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2788138
  • Target Alle GCH1 Antikörper anzeigen
    GCH1 (GTP Cyclohydrolase 1 (GCH1))
    Bindungsspezifität
    • 15
    • 11
    • 8
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    C-Term
    Reaktivität
    • 39
    • 23
    • 9
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd, Meerschweinchen, Saccharomyces cerevisiae, Zebrafisch (Danio rerio)
    Wirt
    • 47
    • 7
    • 1
    Kaninchen
    Klonalität
    • 52
    • 3
    Polyklonal
    Konjugat
    • 21
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GCH1 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 29
    • 18
    • 13
    • 13
    • 6
    • 5
    • 4
    • 3
    Western Blotting (WB)
    Sequenz
    LRPAGVGVVV EATHMCMVMR GVQKMNSKTV TSTMLGVFRE DPKTREEFLT
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 93%
    Produktmerkmale
    This is a rabbit polyclonal antibody against GCH1. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human GCH1
    Top Product
    Discover our top product GCH1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 250 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    GCH1 (GTP Cyclohydrolase 1 (GCH1))
    Andere Bezeichnung
    GCH1 (GCH1 Produkte)
    Synonyme
    DYT14 antikoerper, DYT5 antikoerper, DYT5a antikoerper, GCH antikoerper, GTP-CH-1 antikoerper, GTPCH1 antikoerper, HPABH4B antikoerper, GTP-CH antikoerper, GTPCH antikoerper, Gch antikoerper, MGC89622 antikoerper, gch1a antikoerper, wu:fc16b10 antikoerper, zgc:195269 antikoerper, GTP cyclohydrolase 1 antikoerper, GTP cyclohydrolase 1-like antikoerper, GCH1 antikoerper, Gch1 antikoerper, gch1 antikoerper, Weevi_1190 antikoerper, Halhy_0838 antikoerper, Sinme_1220 antikoerper, Sphch_1077 antikoerper, LOC100136794 antikoerper
    Hintergrund
    This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.
    Alias Symbols: DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
    Protein Interaction Partner: GCH1, CALML6, CAMKK1, CSNK1G1, CALML5, PACSIN3, RGS19, MAP2K4, MAPK12, MAP2K5, MAPK10, PRKAR2B, PRKAR2A, PPM1B, CSNK2B, CSNK2A1, GIT2, YWHAZ, CNRIP1, RAB26, AHSA1, SP3, RLF, HSPA8, GCHFR, ATP1B1, CDC37, SH3GL2, OSBPL9, RPH3A,
    Protein Size: 250
    Molekulargewicht
    28 kDa
    Gen-ID
    2643
    NCBI Accession
    NM_000161, NP_000152
    UniProt
    P30793
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