PCSK4 Antikörper (N-Term)

Produktnummer ABIN2787781

Produktdetails anti-PCSK4 Antikörper

Target: PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCSK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VSSWAVQVSQ GNREVERLAR KFGFVNLGPI FPDGQYFHLR HRGVVQQSLT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against PCSK4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCSK4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 755 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PCSK4

Target: PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))

Andere Bezeichnung: PCSK4 (PCSK4 Produkte)

Synonyme: PC4 antikoerper, SPC5 antikoerper, AI647044 antikoerper, L21221 antikoerper, NEC 3 antikoerper, NEC3 antikoerper, PCSK4 antikoerper, pc4 antikoerper, spc5 antikoerper, MGC146505 antikoerper, pcsk4 antikoerper, proprotein convertase subtilisin/kexin type 4 antikoerper, proprotein convertase subtilisin/kexin type 4 L homeolog antikoerper, PCSK4 antikoerper, Pcsk4 antikoerper, pcsk4 antikoerper, pcsk4.L antikoerper

Hintergrund: PCSK4 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK4 plays a role in transcriptional coactivation. PCSK4 may be involved in stabilizing the multiprotein transcription complex.Proprotein convertases, including PCSK4, are calcium-dependent serine proteases related to bacterial subtilisins and to yeast kexin. These enzymes process precursor proteins to their active forms by selective cleavage of the polypeptide at sites following paired basic amino acids. In mammals, this family comprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM 600488), furin (FUR, MIM 136950), and PACE4 (MIM 167405). Substrates for these enzymes range from prohormones to precursors for growth factors to cell surface receptors and viral surface glycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-31 AC027307.5 80201-80231 c 32-257 AY358963.1 32-257 258-655 AK057235.1 452-849 656-2528 AY358963.1 656-2528 2529-2606 AL043305.1 210-287 2607-2674 AA453604.1 1-68 c
Alias Symbols: DKFZp434B217, MGC34749, PC4, SPC5
Protein Interaction Partner: IGF2,
Protein Size: 755

Molekulargewicht: 83 kDa

Gen-ID: 54760

NCBI Accession: NM_017573, NP_060043

UniProt: Q6UW60