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RUNX1T1 Antikörper (Middle Region)

RUNX1T1 Reaktivität: Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Kaninchen, Meerschweinchen, Pferd, Rind (Kuh), Schwein WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2787562
  • Target Alle RUNX1T1 Antikörper anzeigen
    RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))
    Bindungsspezifität
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 35
    • 20
    • 10
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Kaninchen, Meerschweinchen, Pferd, Rind (Kuh), Schwein
    Wirt
    • 32
    • 3
    Kaninchen
    Klonalität
    • 33
    • 2
    Polyklonal
    Konjugat
    • 24
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RUNX1T1 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 11
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    RQCNLQQFIQ QTGAALPPPP RPDRGPPGTQ GPLPPAREES LLGAPSESHA
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 86%, Zebrafish: 93%
    Produktmerkmale
    This is a rabbit polyclonal antibody against RUNX1T1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human RUNX1T1
    Top Product
    Discover our top product RUNX1T1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 577 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))
    Andere Bezeichnung
    RUNX1T1 (RUNX1T1 Produkte)
    Synonyme
    MTG8 antikoerper, si:ch211-232j17.1 antikoerper, wu:fi14b07 antikoerper, zgc:154044 antikoerper, AML1T1 antikoerper, CBFA2T1 antikoerper, CDR antikoerper, ETO antikoerper, ZMYND2 antikoerper, Cbfa2t1h antikoerper, Cbfa2t1 antikoerper, runt-related transcription factor 1; translocated to, 1 (cyclin D-related) antikoerper, RUNX1 translocation partner 1 L homeolog antikoerper, RUNX1 translocation partner 1 antikoerper, runx1t1 antikoerper, runx1t1.L antikoerper, RUNX1T1 antikoerper, Runx1t1 antikoerper
    Hintergrund
    RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
    Alias Symbols: AML1T1, CBFA2T1, CDR, ETO, MGC2796, MTG8, MTG8b, ZMYND2
    Protein Interaction Partner: EPS8, NECAB2, ABI3, GSE1, MID2, SPRY2, HOMER3, LPXN, ZMYM4, STX11, MEOX2, CCDC36, TRIM42, SPERT, CREB3L1, LZTS2, EFHC2, CPSF7, C19orf57, PRDM14, CBFA2T2, NCOR1, UBQLN4, ATN1, BCL6, ETS1, RUNX1, DNMT1, SPEN, RBPJ, UBE2E2, UBC, TRIM33, HDAC1, NCOR2, SIN3A,
    Protein Size: 577
    Molekulargewicht
    64 kDa
    Gen-ID
    862
    NCBI Accession
    NM_004349, NP_004340
    UniProt
    B2R6I9
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