RUNX1T1 Antikörper (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related)) (Middle Region)

Details for Product anti-RUNX1T1 Antibody No. ABIN2787562, Anbieter: Anmelden zum Anzeigen
Antigen
  • MTG8
  • si:ch211-232j17.1
  • wu:fi14b07
  • zgc:154044
  • AML1T1
  • CBFA2T1
  • CDR
  • ETO
  • ZMYND2
  • Cbfa2t1h
  • Cbfa2t1
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
  • runx1t1
  • RUNX1T1
  • Runx1t1
Epitop
Middle Region
5
4
3
2
2
2
2
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus), Zebrafisch
38
17
14
8
6
5
5
4
4
4
4
3
3
1
1
Wirt
Kaninchen
29
9
Klonalität
Polyklonal
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
28
15
7
5
3
2
1
1
Optionen
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human RUNX1T1
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN983327.
Sequenz RQCNLQQFIQ QTGAALPPPP RPDRGPPGTQ GPLPPAREES LLGAPSESHA
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 86%, Zebrafish: 93%
Produktmerkmale This is a rabbit polyclonal antibody against RUNX1T1. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung RUNX1T1 (RUNX1T1 Antibody Abstract)
Hintergrund RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
Alias Symbols: AML1T1, CBFA2T1, CDR, ETO, MGC2796, MTG8, MTG8b, ZMYND2
Protein Interaction Partner: EPS8, NECAB2, ABI3, GSE1, MID2, SPRY2, HOMER3, LPXN, ZMYM4, STX11, MEOX2, CCDC36, TRIM42, SPERT, CREB3L1, LZTS2, EFHC2, CPSF7, C19orf57, PRDM14, CBFA2T2, NCOR1, UBQLN4, ATN1, BCL6, ETS1, RUNX1, DNMT1, SPEN, RBPJ, UBE2E2, UBC, TRIM33, HDAC1, NCOR2, SIN3A,
Protein Size: 577
Molekulargewicht 64 kDa
Gen-ID 862
NCBI Accession NM_004349, NP_004340
UniProt B2R6I9
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 577 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-RUNX1T1 Antikörper (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related)) (Middle Region) (ABIN2787562) WB Suggested Anti-RUNX1T1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: <...
Allgemeine Veröffentlichungen Salat, Liefke, Wiedenmann, Borggrefe, Oswald: "ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes." in: Molecular and cellular biology, Vol. 28, Issue 10, pp. 3502-12, 2008 (PubMed).