UBE2K Antikörper (Middle Region)

Produktnummer ABIN2787511

Produktdetails anti-UBE2K Antikörper

Target: UBE2K (Ubiquitin-Conjugating Enzyme E2K (UBE2K))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Rind (Kuh), Pferd, Kaninchen, Ziege, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2K Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TVLLSLQALL AAAEPDDPQD AVVANQYKQN PEMFKQTARL WAHVYAGAPV

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against UBE2K. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UBE2K

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 200 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu UBE2K

Target: UBE2K (Ubiquitin-Conjugating Enzyme E2K (UBE2K))

Andere Bezeichnung: UBE2K (UBE2K Produkte)

Synonyme: E2-25K antikoerper, HIP2 antikoerper, HYPG antikoerper, LIG antikoerper, UBC1 antikoerper, E2-25k antikoerper, Hip2 antikoerper, Hypg antikoerper, Lig antikoerper, e2-25k antikoerper, hip2 antikoerper, hypg antikoerper, lig antikoerper, AW492011 antikoerper, D5Ertd601e antikoerper, ube2k antikoerper, zgc:103472 antikoerper, zgc:110791 antikoerper, ubiquitin conjugating enzyme E2 K antikoerper, ubiquitin-conjugating enzyme E2K antikoerper, ubiquitin conjugating enzyme E2 K S homeolog antikoerper, ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) antikoerper, ubiquitin-conjugating enzyme E2Ka (UBC1 homolog, yeast) antikoerper, UBE2K antikoerper, Ube2k antikoerper, ube2k.S antikoerper, ube2k antikoerper, ube2kb antikoerper, ube2ka antikoerper

Hintergrund: UBE2K belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.
Alias Symbols: DKFZp564C1216, DKFZp686J24237, E2-25K, HIP2, HYPG, LIG, UBC1
Protein Interaction Partner: DDI1, DTX3, MIPOL1, TRIM39, ANAPC11, RNF138, SIAH1, RNF5, REL, FZR1, UBC, UBA1, MARCH7, AMFR, TP53, MDM2, BAG3, PRRG4, IQCB1, HTT, CDC6, WDR1, TYMS, TXN, TXNDC17, WDR61, ITCH, NEDD4L, WWP2, NXF1, NUB1, PIAS4, CASP12, SUMO1, SUMO2, DIABLO, UBE2I, CCNB1, BR
Protein Size: 200

Molekulargewicht: 22 kDa

Gen-ID: 3093

NCBI Accession: NM_005339, NP_005330

UniProt: P61086