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ERCC8 Antikörper (Middle Region)

ERCC8 Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Pferd, Rind (Kuh), Schwein, Meerschweinchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2787479
  • Target Alle ERCC8 Antikörper anzeigen
    ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
    Bindungsspezifität
    • 15
    • 8
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 47
    • 32
    • 22
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte, Hund, Kaninchen, Pferd, Rind (Kuh), Schwein, Meerschweinchen
    Wirt
    • 41
    • 6
    Kaninchen
    Klonalität
    • 43
    • 4
    Polyklonal
    Konjugat
    • 28
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ERCC8 Antikörper ist unkonjugiert
    Applikation
    • 47
    • 13
    • 13
    • 11
    • 9
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    VRRASGCLIT LDQHNGKKSQ AVESANTAHN GKVNGLCFTS DGLHLLTVGT
    Homologie
    Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against ERCC8. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human ERCC8
    Top Product
    Discover our top product ERCC8 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 396 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
    Andere Bezeichnung
    ERCC8 (ERCC8 Produkte)
    Synonyme
    zgc:103550 antikoerper, CKN1 antikoerper, CSA antikoerper, UVSS2 antikoerper, Ckn1 antikoerper, 2410022P04Rik antikoerper, 2810431L23Rik antikoerper, 4631412O06Rik antikoerper, B130065P18Rik antikoerper, Csa antikoerper, excision repair cross-complementation group 8 antikoerper, ERCC excision repair 8, CSA ubiquitin ligase complex subunit antikoerper, excision repaiross-complementing rodent repair deficiency, complementation group 8 antikoerper, ercc8 antikoerper, ERCC8 antikoerper, Ercc8 antikoerper
    Hintergrund
    ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS).This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
    Alias Symbols: CKN1, CSA
    Protein Interaction Partner: CUL4A, CUL4B, DDB1, RUVBL2, ZNF24, PCNA, H1F0, ERCC6, UVSSA, DDA1, RFWD2, COPS4, COPS6, COPS3, TOP1, TP53, SSBP1, OGG1, MDM2, GTF2H2, CUL5, GPS1, DDB2, COPS2, COPS7A, COPS5, COPS8, RBX1, POLR2A, HMGN1, EP300, UBC, CSNK2B, XAB2, UQCRQ, CBR1,
    Protein Size: 396
    Molekulargewicht
    44 kDa
    Gen-ID
    1161
    NCBI Accession
    NM_000082, NP_000073
    UniProt
    Q13216
    Pathways
    DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus
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