P5CS Antikörper (N-Term)

Produktnummer ABIN2786580

Produktdetails anti-P5CS Antikörper

Target: P5CS (ALDH18A1) (Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Hund, Pferd, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser P5CS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SVIRHVRSWS NIPFITVPLS RTHGKSFAHR SELKHAKRIV VKLGSAVVTR

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against ALDH18A1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ALDH18A1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 793 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu P5CS

Target: P5CS (ALDH18A1) (Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1))

Andere Bezeichnung: ALDH18A1 (ALDH18A1 Produkte)

Synonyme: ALDH18A1 antikoerper, ARCL3A antikoerper, GSAS antikoerper, P5CS antikoerper, PYCS antikoerper, 2810433K04Rik antikoerper, AI429789 antikoerper, Pycs antikoerper, cb842 antikoerper, cb899 antikoerper, pycs antikoerper, sb:cb881 antikoerper, wu:fa91f10 antikoerper, wu:fi05f11 antikoerper, wu:fi17d12 antikoerper, aldehyde dehydrogenase 18 family member A1 antikoerper, aldehyde dehydrogenase 18 family, member A1 antikoerper, aldehyde dehydrogenase 18 family member A1 L homeolog antikoerper, ALDH18A1 antikoerper, aldh18a1 antikoerper, Aldh18a1 antikoerper, aldh18a1.L antikoerper

Hintergrund: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases.This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.
Alias Symbols: GSAS, MGC117316, P5CS, PYCS, ARCL3A
Protein Interaction Partner: CMTM5, AGTRAP, UBC, SUMO2, SUMO3, STAU1, MDM2, LATS2, ADRB2, VCP, TIMM13, SUMO1, NONO, MTHFD1, ILF3, ILF2, DDX1, CUL3, CDK2, SIRT7, TCF3, Haus1, Mical3, Trim69, Cbx1, HDAC5, MYC, ICT1, ZRANB1,
Protein Size: 793

Molekulargewicht: 87 kDa

Gen-ID: 5832

NCBI Accession: NM_001017423, NP_001017423

UniProt: P54886