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PMS2 Antikörper (Middle Region)

PMS2 Reaktivität: Human, Ratte, Rind (Kuh), Meerschweinchen, Hund, Pferd, Kaninchen, Saccharomyces cerevisiae WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2786522
  • Target Alle PMS2 Antikörper anzeigen
    PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
    Bindungsspezifität
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    Human, Ratte, Rind (Kuh), Meerschweinchen, Hund, Pferd, Kaninchen, Saccharomyces cerevisiae
    Wirt
    • 45
    • 14
    • 1
    Kaninchen
    Klonalität
    • 36
    • 24
    Polyklonal
    Konjugat
    • 43
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PMS2 Antikörper ist unkonjugiert
    Applikation
    • 38
    • 26
    • 15
    • 14
    • 9
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    INKKVVPLDF SMSSLAKRIK QLHHEAQQSE GEQNYRKFRA KICPGENQAA
    Homologie
    Cow: 85%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Rabbit: 92%, Rat: 92%, Yeast: 91%
    Produktmerkmale
    This is a rabbit polyclonal antibody against PMS2. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PMS2
    Top Product
    Discover our top product PMS2 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 862 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
    Andere Bezeichnung
    PMS2 (PMS2 Produkte)
    Synonyme
    HNPCC4 antikoerper, PMS2CL antikoerper, PMSL2 antikoerper, AW555130 antikoerper, Pmsl2 antikoerper, PMS1 homolog 2, mismatch repair system component antikoerper, PMS1 homolog2, mismatch repair system component antikoerper, mismatch repair endonuclease PMS2 antikoerper, PMS2 antikoerper, Pms2 antikoerper, LOC463257 antikoerper, LOC107984056 antikoerper
    Hintergrund
    PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
    Alias Symbols: HNPCC4, PMS2CL, PMSL2
    Protein Interaction Partner: UBC, MLH1, PCNA, PMS2P1, NSF, MSH2, LMNA, MSH6, SPRTN, BRIP1, FAN1, CLSPN, TOPBP1, PSD2, MMS19, ATAD3A, NSUN2, UBR5, COPG2, PSD3, COPG1, RUVBL2, EXO1, AIFM1, RUVBL1, XPO1, SMARCA4, RFC2, PSMD5, PSMC6, PSMC3, PSMC2, PSMC1, PRKDC, PPP2CA, PIK3C2A, MSH3, MCM
    Protein Size: 862
    Molekulargewicht
    96 kDa
    Gen-ID
    5395
    NCBI Accession
    NM_000535, NP_000526
    UniProt
    P54278
    Pathways
    DNA Reparatur, Production of Molecular Mediator of Immune Response
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