Ubiquilin 1 Antikörper (Middle Region)

Produktnummer ABIN2785977

Produktdetails anti-Ubiquilin 1 Antikörper

Target: Ubiquilin 1 (UBQLN1)

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Schaf, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ubiquilin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: QFGGNPFASL VSNTSSGEGS QPSRTENRDP LPNPWAPQTS QSSSASSGTA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against UBQLN1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UBQLN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 589 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Ubiquilin 1

Target: Ubiquilin 1 (UBQLN1)

Andere Bezeichnung: UBQLN1 (UBQLN1 Produkte)

Synonyme: UBQLN1 antikoerper, DA41 antikoerper, DSK2 antikoerper, PLIC-1 antikoerper, UBQN antikoerper, XDRP1 antikoerper, 1110046H03Rik antikoerper, 1810030E05Rik antikoerper, AU019746 antikoerper, C77538 antikoerper, D13Ertd372e antikoerper, Da41 antikoerper, Dsk2 antikoerper, Plic-1 antikoerper, Plic1 antikoerper, Xdrp1 antikoerper, ubiquilin 1 antikoerper, UBQLN1 antikoerper, Ubqln1 antikoerper

Hintergrund: UBQLN1 is an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DA41, DSK2, FLJ90054, PLIC-1, XDRP1, UBQN
Protein Interaction Partner: MLLT6, MCM7, IL6ST, IGLC1, IGL, SLC29A2, HK2, GYPB, GRM2, GPX3, GABRD, FN1, FKBP2, FCGR2A, DEFA6, CTAG1B, CSTF2, COL10A1, COL1A2, CALU, IGLV2-14, FAM127B, CSTF2T, FAM127C, TMEM31, AGR3, ITPRIPL1, TRIM32, ACOT7, PLA2G16, SMR3B, AGR2, PSMD6, NUPL1, IST1, LI
Protein Size: 589

Molekulargewicht: 62 kDa

Gen-ID: 29979

NCBI Accession: NM_013438, NP_038466

UniProt: Q5T6J9