Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) (Middle Region) Antikörper

Details zu Produkt Nr. ABIN2785912, Anbieter: Anmelden zum Anzeigen
Antigen
  • APPL
  • DIP13alpha
  • 2900057D21Rik
  • 7330406P05Rik
  • AI585782
  • AW209077
  • BB022931
  • C88264
  • DIP13
  • RGD1309388
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
  • APPL1
  • Appl1
Epitop
Middle Region
15
9
5
5
4
3
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
64
32
20
6
4
3
3
2
2
2
1
1
Wirt
Kaninchen
43
20
3
Klonalität
Polyklonal
Konjugat
Unkonjugiert
1
1
1
1
1
1
Applikation
Western Blotting (WB)
60
33
17
12
3
3
1
1
1
Optionen
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human APPL1
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN973345.
Sequenz GQAKAFGQGG RRTNPFGESG GSTKSETEDS ILHQLFIVRF LGSMEVKSDD
Homologie Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 75%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against APPL1. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung APPL1 (APPL1 Antibody Abstract)
Hintergrund The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A
Alias Symbols: APPL, DIP13alpha
Protein Interaction Partner: RHEBL1, UBE2O, APPL2, APPL1, FARS2, MEOX1, MAGEA9, UBC, KIAA1468, CLUH, TTC4, TRAF6, ADIPOR1, HDAC5, HDAC3, HDAC2, PIK3R1, AR, AKT1, CMTM4, PLEKHF2, KXD1, DPYSL5, EGFR, RAB21, VCP, RAB5A, AKT2, ADIPOR2, FSHR, ELAVL1, MTA2, RBBP7, RUVBL2, RBBP4, HDAC1, TRA
Protein Size: 709
Molekulargewicht 80 kDa
Gen-ID 26060
NCBI Accession NM_012096, NP_036228
UniProt Q9UKG1
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 709 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) (Middle Region) Antikörper (ABIN2785912) WB Suggested Anti-APPL1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive...
Allgemeine Veröffentlichungen McCrea, Paradise, Tomasini, Addis, Melis, De Matteis, De Camilli: "All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding." in: Biochemical and biophysical research communications, Vol. 369, Issue 2, pp. 493-9, 2008 (PubMed).