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ULK1 Antikörper (N-Term)

ULK1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Zebrafisch (Danio rerio), Pferd, Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2785618
  • Target Alle ULK1 Antikörper anzeigen
    ULK1 (Unc-51 Like Kinase 1 (ULK1))
    Bindungsspezifität
    • 25
    • 16
    • 16
    • 14
    • 13
    • 11
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 193
    • 76
    • 65
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Zebrafisch (Danio rerio), Pferd, Kaninchen
    Wirt
    • 196
    • 3
    • 2
    Kaninchen
    Klonalität
    • 189
    • 12
    Polyklonal
    Konjugat
    • 54
    • 23
    • 19
    • 18
    • 13
    • 11
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ULK1 Antikörper ist unkonjugiert
    Applikation
    • 111
    • 95
    • 30
    • 26
    • 26
    • 25
    • 20
    • 12
    • 10
    • 9
    • 6
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequenz
    PEVIMSQHYD GKADLWSIGT IVYQCLTGKA PFQASSPQDL RLFYEKNKTL
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against ULK1. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human ULK1
    Top Product
    Discover our top product ULK1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeat freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    ULK1 (Unc-51 Like Kinase 1 (ULK1))
    Andere Bezeichnung
    ULK1 (ULK1 Produkte)
    Synonyme
    ATG1 antikoerper, ATG1A antikoerper, UNC51 antikoerper, Unc51.1 antikoerper, hATG1 antikoerper, si:dkey-11o18.7 antikoerper, ulk1 antikoerper, ULK1 antikoerper, AU041434 antikoerper, mKIAA0722 antikoerper, zgc:195008 antikoerper, unc-51 like autophagy activating kinase 1 antikoerper, unc-51 like kinase 1 antikoerper, unc-51 like autophagy activating kinase 1a antikoerper, ULK1 antikoerper, Ulk1 antikoerper, ulk1b antikoerper, ulk1a antikoerper
    Hintergrund
    ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.
    Alias Symbols: ATG1, ATG1A, UNC51, Unc51.1, hATG1
    Protein Interaction Partner: SESN2, SQSTM1, ATG16L1, EXOC8, EXOC2, BECN1, RALB, AMBRA1, ULK1, UBC, TRAF6, MBP, ATG13, MAP1LC3C, MAP1LC3A, MAP1LC3B, GABARAPL1, GABARAPL2, GABARAP, MLST8, RPTOR, MTOR, PPP1CA, ATG4B, CDC37, G3BP1, RB1CC1, USP10, PRKAG1, PRKAB2, PRKAA2, PRKAA1, SYNGAP1,
    Protein Size: 1050
    Molekulargewicht
    112 kDa
    Gen-ID
    8408
    NCBI Accession
    NM_003565, NP_003556
    UniProt
    O75385
    Pathways
    Regulation of Cell Size, Autophagie
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