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TAB1 Antikörper (N-Term)

TAB1 Reaktivität: Human, Maus, Ratte, Schwein, Hund, Kaninchen, Meerschweinchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2785275
  • Target Alle TAB1 Antikörper anzeigen
    TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
    Bindungsspezifität
    • 15
    • 15
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 93
    • 40
    • 27
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Schwein, Hund, Kaninchen, Meerschweinchen
    Wirt
    • 97
    • 9
    • 2
    Kaninchen
    Klonalität
    • 100
    • 8
    Polyklonal
    Konjugat
    • 41
    • 9
    • 7
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser TAB1 Antikörper ist unkonjugiert
    Applikation
    • 69
    • 48
    • 26
    • 26
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequenz
    MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
    Homologie
    Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against MAP3K7IP1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human MAP3K7IP1
    Top Product
    Discover our top product TAB1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 462 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
    Andere Bezeichnung
    MAP3K7IP1 (TAB1 Produkte)
    Synonyme
    3'-Tab1 antikoerper, MAP3K7IP1 antikoerper, 2310012M03Rik antikoerper, Map3k7ip1 antikoerper, b2b449Clo antikoerper, TGF-beta activated kinase 1 (MAP3K7) binding protein 1 antikoerper, TGF-beta activated kinase 1/MAP3K7 binding protein 1 antikoerper, TAB1 antikoerper, Tab1 antikoerper
    Hintergrund
    The specific function of the protein remains unknown.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
    Alias Symbols: 3'-Tab1, MGC57664, TAB1, MAP3K7IP1
    Protein Interaction Partner: MAGED1, BAG2, MAP3K7, TIRAP, MDM2, SLMAP, NPM1, BIRC3, TRIP6, PPP2R1A, PPP2CB, GRB2, FN1, CDK5RAP3, TAB2, CORO1A, WTAP, MAPK8IP1, UBC, MAPK14, BST2, MAPK12, HSP90AA1, NOTCH1, IKBKB, GRK5, EGFR, STE11, BIRC7, NAIP, XIAP, OGT, TAB3, NR2C2, ARRB2, ARAP1, ACA
    Protein Size: 462
    Molekulargewicht
    50 kDa
    Gen-ID
    10454
    NCBI Accession
    NM_153497, NP_705717
    UniProt
    Q8IZW2
    Pathways
    TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades
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