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PACRG Antikörper (Middle Region)

PACRG Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Pferd, Meerschweinchen, Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2785168
  • Target Alle PACRG Antikörper anzeigen
    PACRG (PARK2 Co-Regulated (PACRG))
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    Middle Region
    Reaktivität
    • 41
    • 19
    • 18
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Pferd, Meerschweinchen, Kaninchen
    Wirt
    • 40
    • 1
    Kaninchen
    Klonalität
    • 41
    Polyklonal
    Konjugat
    • 17
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PACRG Antikörper ist unkonjugiert
    Applikation
    • 40
    • 18
    • 14
    • 5
    • 4
    • 2
    • 1
    Western Blotting (WB)
    Sequenz
    GAIMARCNLD HLGSSDPPTS ASQVAEIIVN SGDGIDYSQQ KRENIGDLIQ
    Homologie
    Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against PACRG. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PACRG
    Top Product
    Discover our top product PACRG Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 296 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Taylor, Song, Huang, Farrer, Delatycki, Halliday, Lockhart: "Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases." in: Neurobiology of disease, Vol. 27, Issue 2, pp. 238-47, (2007) (PubMed).

    Verrengia Guerrero, Taylor, Simkiss: "Modelling 2,4-dichlorophenol bioavailability and bioaccumulation by the freshwater fingernail clam Sphaerium corneum using artificial particles and humic acids." in: Environmental pollution (Barking, Essex : 1987), Vol. 145, Issue 1, pp. 238-44, (2006) (PubMed).

  • Target
    PACRG (PARK2 Co-Regulated (PACRG))
    Andere Bezeichnung
    PACRG (PACRG Produkte)
    Synonyme
    PACRG antikoerper, GLUP antikoerper, HAK005771 antikoerper, PARK2CRG antikoerper, RP3-495O10.2 antikoerper, zgc:101786 antikoerper, RGD1561027 antikoerper, 1700008H23Rik antikoerper, parkin coregulated antikoerper, PARK2 co-regulated antikoerper, PARK2 coregulated antikoerper, PACRG antikoerper, pacrg antikoerper, Pacrg antikoerper
    Hintergrund
    PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death.This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: FLJ32724, GLUP, HAK005771, PARK2CRG, RP3-495O10.2
    Protein Interaction Partner: UBC, TUBB, HOPX, CCT5, CCT8, CCT2, CCT4, CCT7, STUB1, TUBA1A, VCP, CCT3, TCP1, PARK2, HSP90AA1, HSPA4, DNAJA1, GPR37, CCT6A, APP,
    Protein Size: 296
    Molekulargewicht
    33 kDa
    Gen-ID
    135138
    NCBI Accession
    NM_152410, NP_689623
    UniProt
    Q96M98
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