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Retinoblastoma Binding Protein 8 Antikörper (C-Term)

RBBP8 Reaktivität: Human, Schwein, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2784374
  • Target Alle Retinoblastoma Binding Protein 8 (RBBP8) Antikörper anzeigen
    Retinoblastoma Binding Protein 8 (RBBP8)
    Bindungsspezifität
    • 9
    • 9
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 63
    • 29
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Schwein, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd
    Wirt
    • 60
    • 3
    Kaninchen
    Klonalität
    • 60
    • 3
    Polyklonal
    Konjugat
    • 35
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Retinoblastoma Binding Protein 8 Antikörper ist unkonjugiert
    Applikation
    • 36
    • 25
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    ETVDMDCTLV SETVLLKMKK QEQKGEKSSN EERKMNDSLE DMFDRTTHEE
    Homologie
    Cow: 79%, Dog: 86%, Guinea Pig: 83%, Horse: 79%, Human: 100%, Pig: 100%, Rabbit: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against RBBP8. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human RBBP8
    Top Product
    Discover our top product RBBP8 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 867 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Retinoblastoma Binding Protein 8 (RBBP8)
    Andere Bezeichnung
    RBBP8 (RBBP8 Produkte)
    Synonyme
    COM1 antikoerper, CTIP antikoerper, JWDS antikoerper, RIM antikoerper, SAE2 antikoerper, SCKL2 antikoerper, 9930104E21Rik antikoerper, CtIP antikoerper, RBBP-8 antikoerper, RGD1308872 antikoerper, RBBP8 antikoerper, DKFZp469K0714 antikoerper, RB binding protein 8, endonuclease antikoerper, retinoblastoma binding protein 8, endonuclease antikoerper, retinoblastoma binding protein 8 L homeolog antikoerper, retinoblastoma binding protein 8 antikoerper, RBBP8 antikoerper, Rbbp8 antikoerper, rbbp8.L antikoerper, rbbp8 antikoerper
    Hintergrund
    RBBP8 is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
    Alias Symbols: CTIP, RIM, JWDS, SAE2, SCKL2
    Protein Interaction Partner: LMO4, PIN1, LMO1, MDM2, BRCA1, RBL1, TMEM54, PRRG4, RGS17, IKBKG, IGFBP7, EEF1A1, CTBP2, CLU, MAP2K4, RAF1, RBL2, PCNA, ZNF350, NBN, UIMC1, PALB2, BARD1, SPEN, RAD50, CTBP1, RB1, UBC, FXR2, RBBP8, IKZF1, LIMS1, SIAH2, SIAH1, LMO2, WDYHV1, ATM, TGIF2, IKZF
    Protein Size: 867
    Molekulargewicht
    98 kDa
    Gen-ID
    5932
    NCBI Accession
    NM_203292, NP_976037
    UniProt
    A6NKN2
    Pathways
    Zellzyklus, DNA Reparatur
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