SENP6 Antikörper (SUMO1/sentrin Specific Protease 6) (C-Term)

Details for Product anti-SENP6 Antibody No. ABIN2784244, Anbieter: Anmelden zum Anzeigen
Antigen
  • 2810017C20Rik
  • E130319N12Rik
  • Susp1
  • mKIAA0797
  • SSP1
  • SUSP1
  • SUMO1/sentrin specific peptidase 6
  • SUMO/sentrin specific peptidase 6
  • SENP6
  • Senp6
Epitop
C-Term
41
36
14
14
4
3
2
2
2
2
2
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
117
15
7
5
4
4
2
2
2
2
2
1
Wirt
Kaninchen
86
30
4
Klonalität
Polyklonal
Konjugat
Dieser SENP6 Antikörper ist unkonjugiert
10
10
10
10
10
10
Applikation
Western Blotting (WB)
92
69
49
14
12
7
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN983535.
Sequenz LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS
Homologie Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against Senp6. It was validated on Western Blot.
Reinigung Affinity Purified
Andere Bezeichnung Senp6 (SENP6 Antibody Abstract)
Hintergrund Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Alias Symbols: 2810017C20Rik, E130319N12Rik, MGC38009, Susp1, mKIAA0797
Protein Interaction Partner: Sumo3, Ikbkg,
Protein Size: 1132
Molekulargewicht 127 kDa
Gen-ID 215351
NCBI Accession NM_146003, NP_666115
UniProt Q6P7W0
Forschungsgebiet Proteolysis / Ubiquitin
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 1132 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term) antibody (ABIN2784244) Host: Rabbit Target Name: Senp6 Antibody Dilution: 1.0ug/ml Sample Type: Mouse Lung
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