SENP6 Antikörper (C-Term)
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- Target Alle SENP6 Antikörper anzeigen
- SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Pferd, Hund, Schwein, Kaninchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SENP6 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS
- Homologie
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against Senp6. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Top Product
- Discover our top product SENP6 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 1132 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
- Andere Bezeichnung
- Senp6 (SENP6 Produkte)
- Synonyme
- SSP1 antikoerper, SUSP1 antikoerper, 2810017C20Rik antikoerper, E130319N12Rik antikoerper, Susp1 antikoerper, mKIAA0797 antikoerper, fc83h02 antikoerper, im:7148342 antikoerper, wu:fc83h02 antikoerper, zgc:171230 antikoerper, SUMO1/sentrin specific peptidase 6 antikoerper, SUMO/sentrin specific peptidase 6 antikoerper, SUMO1/sentrin specific peptidase 6a antikoerper, SENP6 antikoerper, Senp6 antikoerper, senp6a antikoerper
- Hintergrund
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Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Alias Symbols: 2810017C20Rik, E130319N12Rik, MGC38009, Susp1, mKIAA0797
Protein Interaction Partner: Sumo3, Ikbkg,
Protein Size: 1132 - Molekulargewicht
- 127 kDa
- Gen-ID
- 215351
- NCBI Accession
- NM_146003, NP_666115
- UniProt
- Q6P7W0
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