DISP1 Antikörper (Middle Region)

Produktnummer ABIN2784069

Produktdetails anti-DISP1 Antikörper

Target: DISP1 (Dispatched Homolog 1 (DISP1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Pferd, Schwein, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DISP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FVLCDVWNYT KFDKPHAETS ETVSITLQHA ALSMFVTSFT TAAAFYANYV

Homologie: Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 100%, Rat: 86%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against DISP1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DISP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1524 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DISP1

Target: DISP1 (Dispatched Homolog 1 (DISP1))

Andere Bezeichnung: DISP1 (DISP1 Produkte)

Synonyme: DISP1 antikoerper, DISPA antikoerper, 1190008H24Rik antikoerper, DispA antikoerper, con antikoerper, zgc:111866 antikoerper, dispatched antikoerper, dispatched RND transporter family member 1 antikoerper, dispatched homolog 1 (Drosophila) antikoerper, CpipJ_CPIJ008642 antikoerper, DISP1 antikoerper, Disp1 antikoerper, disp1 antikoerper

Hintergrund: DISP1 functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo.
Alias Symbols: DISPA, DKFZP434I0428, FLJ43740, MGC104180, MGC13130, MGC16796
Protein Interaction Partner: LAPTM5, UBC,
Protein Size: 1524

Molekulargewicht: 171 kDa

Gen-ID: 84976

NCBI Accession: NM_032890, NP_116279

UniProt: Q96F81

Pathways: Hedgehog Signalweg