NDE1 Antikörper (Middle Region)

Produktnummer ABIN2783161

Produktdetails anti-NDE1 Antikörper

Target: NDE1

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NDE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: AHRGPSSSLN TPGSFRRGLD DSTGGTPLTP AARISALNIV GDLLRKVGAL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against NDE1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NDE1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 335 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NDE1 Antikörper (ABIN2783161)

Burdick, Kamiya, Hodgkinson, Lencz, DeRosse, Ishizuka, Elashvili, Arai, Goldman, Sawa, Malhotra: "Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding." in: Human molecular genetics, Vol. 17, Issue 16, pp. 2462-73, (2008) (PubMed).

Details zu NDE1

Target: NDE1

Andere Bezeichnung: NDE1 (NDE1 Produkte)

Synonyme: 2810027M15Rik antikoerper, AU042936 antikoerper, AW822251 antikoerper, Nude antikoerper, mNudE antikoerper, HOM-TES-87 antikoerper, LIS4 antikoerper, NDE antikoerper, NUDE antikoerper, NUDE1 antikoerper, fb82g01 antikoerper, im:7141877 antikoerper, wu:fb82g01 antikoerper, zgc:114109 antikoerper, nudE neurodevelopment protein 1 antikoerper, Nde1 antikoerper, NDE1 antikoerper, nde1 antikoerper

Hintergrund: NDE1 is required for centrosome duplication and formation and function of the mitotic spindle. It is essential for the development of the cerebral cortex. NDE1 may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex
Alias Symbols: FLJ20101, HOM-TES-87, NUDE, NUDE1, LIS4
Protein Interaction Partner: FAM9B, LZTS2, USHBP1, NDEL1, ZNF398, NDE1, WAC, UBQLN1, MED4, DISC1, TFIP11, CEP250, NDC80, ARNT2, BZRAP1, MKRN3, TTC1, TRIM27, REL, HOXA2, GOLGA2, AR, YWHAQ, PAFAH1B1, ZNF365, YWHAG, TUBG1, MAPK1, CDK1,
Protein Size: 335

Molekulargewicht: 38 kDa

Gen-ID: 54820

NCBI Accession: NM_017668, NP_060138