KIRREL Antikörper (Middle Region)

Produktnummer ABIN2782952

Produktdetails anti-KIRREL Antikörper

Target: KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Pferd, Rind (Kuh), Hund, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIRREL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FLEVGTLERY TVERTNSGSG VLSTLTINNV MEADFQTHYN CTAWNSFGPG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KIRREL. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KIRREL

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 757 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-KIRREL Antikörper (ABIN2782952)

Ito, Sugihara, Asaka, Toyama, Yoshihara, Furuichi, Wada, Asano: "Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice." in: PLoS ONE, Vol. 7, Issue 1, pp. e29873, (2012) (PubMed).

Details zu KIRREL

Target: KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))

Andere Bezeichnung: KIRREL (NEPH1 Produkte)

Synonyme: NEPH1 antikoerper, 6720469N11Rik antikoerper, Kirrel1 antikoerper, Neph1 antikoerper, nephrin related antikoerper, kirre like nephrin family adhesion molecule 1 antikoerper, kin of IRRE like (Drosophila) antikoerper, Smp_104390 antikoerper, Smp_140170 antikoerper, KIRREL1 antikoerper, Kirrel antikoerper, Kirrel1 antikoerper

Hintergrund: KIRREL (NEPH1) is a member of the nephrin-like protein family, which includes NEPH2 and NEPH3. The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2, MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-337 AY302131.1 1-337 338-3211 BC109193.1 1-2874 3212-3609 AK001707.1 1904-2301 3610-3628 BC082969.1 2273-2291
Alias Symbols: FLJ10845, MGC129542, MGC129543, NEPH1
Protein Interaction Partner: UBC, SAV1, LATS1, GRB2, KIRREL, NPHS2, NPHS1, TJP1,
Protein Size: 757

Molekulargewicht: 84 kDa

Gen-ID: 55243

NCBI Accession: NM_018240, NP_060710

UniProt: Q96J84

Pathways: Regulation of Actin Filament Polymerization