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Seladin 1 Antikörper (N-Term)

DHCR24 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Pferd WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2782831
  • Target Alle Seladin 1 (DHCR24) Antikörper anzeigen
    Seladin 1 (DHCR24) (24-Dehydrocholesterol Reductase (DHCR24))
    Bindungsspezifität
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 32
    • 24
    • 21
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Pferd
    Wirt
    • 30
    • 2
    Kaninchen
    Klonalität
    • 32
    Polyklonal
    Konjugat
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Seladin 1 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 13
    • 13
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    FLLPLSLIFD IYYYVRAWVV FKLSSAPRLH EQRVRDIQKQ VREWKEQGSK
    Homologie
    Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against DHCR24. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human DHCR24
    Top Product
    Discover our top product DHCR24 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 516 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Seladin 1 (DHCR24) (24-Dehydrocholesterol Reductase (DHCR24))
    Andere Bezeichnung
    DHCR24 (DHCR24 Produkte)
    Synonyme
    MGC82737 antikoerper, zgc:101638 antikoerper, DCE antikoerper, Nbla03646 antikoerper, SELADIN1 antikoerper, seladin-1 antikoerper, 2310076D10Rik antikoerper, 5830417J06Rik antikoerper, mKIAA0018 antikoerper, 24-dehydrocholesterol reductase antikoerper, 24-dehydrocholesterol reductase S homeolog antikoerper, delta(24)-sterol reductase antikoerper, DHCR24 antikoerper, dhcr24.S antikoerper, dhcr24 antikoerper, LOC5575872 antikoerper, CpipJ_CPIJ000670 antikoerper, Dhcr24 antikoerper
    Hintergrund
    DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: KIAA0018, Nbla03646, SELADIN1, seladin-1, DCE
    Protein Interaction Partner: UBC, env, UBL4A, TP53, MDM2,
    Protein Size: 516
    Molekulargewicht
    58 kDa
    Gen-ID
    1718
    NCBI Accession
    NM_014762, NP_055577
    UniProt
    Q15392
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