HRK Antikörper (N-Term)

Produktnummer ABIN2782598

Produktdetails anti-HRK Antikörper

Target: HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HRK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MCPCPLHRGR GPPAVCACSA GRLGLRSSAA QLTAARLKAL GDELHQRTMW

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 83%, Rabbit: 100%, Rat: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against HRK. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HRK

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 91 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HRK Antikörper (ABIN2782598)

Lucas, Milani, Butterworth, Carmell, Scott, Clark, Cohen, Varadarajan: "High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia." in: Leukemia, Vol. 30, Issue 6, pp. 1273-81, (2016) (PubMed).

Details zu HRK

Target: HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))

Andere Bezeichnung: HRK (HRK Produkte)

Synonyme: DP5 antikoerper, HARAKIRI antikoerper, AI838259 antikoerper, Bid3 antikoerper, harakiri antikoerper, Dp5 antikoerper, harakiri, BCL2 interacting protein antikoerper, harakiri, BCL2 interacting protein (contains only BH3 domain) antikoerper, HRK antikoerper, Hrk antikoerper

Hintergrund: Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 hom
Alias Symbols: DP5, HARAKIRI
Protein Interaction Partner: BCL2L1, ELAVL1, BAD, BCL2L2, C1QBP, BCL2A1, BCL2, MCL1, BNC1,
Protein Size: 91

Molekulargewicht: 10 kDa

Gen-ID: 8739

NCBI Accession: NM_003806, NP_003797

UniProt: O00198