CAD Antikörper (N-Term)

Produktnummer ABIN2782488

Produktdetails anti-CAD Antikörper

Target: CAD (Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase (CAD))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Pferd, Meerschweinchen, Rind (Kuh), Zebrafisch (Danio rerio), Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: AALVLEDGSV LRGQPFGAAV STAGEVVFQT GMVGYPEALT DPSYKAQILV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 86%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CAD. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAD

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 2225 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CAD

Target: CAD (Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase (CAD))

Andere Bezeichnung: CAD (CAD Produkte)

Synonyme: Cpad antikoerper, AU018859 antikoerper, 2410008J01Rik antikoerper, cb456 antikoerper, wu:fc30c12 antikoerper, wu:fc33d01 antikoerper, wu:fc67g02 antikoerper, si:dkey-221h15.3 antikoerper, CAD antikoerper, xcad antikoerper, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase antikoerper, CAD antikoerper, Cad antikoerper, cad antikoerper

Hintergrund: CAD is a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: UBC, TUBG1, TP53, SUMO2, SPRTN, STAU1, LGR4, SUMO1, NEDD8, WWOX, NEDD4, FBXO6, HDAC6, ILK, CDK2, HDAC11, HTRA2, TP63, NOS2, ITGA4, RUVBL1, XPO1, VARS, TUBB2A, TUBA4A, SMARCC2, SMARCA4, RPS3, PSMD1, PSMC2, RUVBL2, TUBB4B, SHC1, SMAD2, GRB2, CBL, CUL3, FBXO
Protein Size: 2225

Molekulargewicht: 243 kDa

Gen-ID: 790

NCBI Accession: NM_004341, NP_004332

UniProt: P27708

Pathways: Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process