CBS Antikörper (N-Term)

Produktnummer ABIN2782348

Produktdetails anti-CBS Antikörper

Target: CBS (Cystathionine-beta-Synthase (CBS))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: RCIIVMPEKM SSEKVDVLRA LGAEIVRTPT NARFDSPESH VGVAWRLKNE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 86%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CBS. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CBS

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 551 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CBS Antikörper (ABIN2782348)

Yamane, Kanno, Nakamura, Fujino, Murayama: "Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine β-synthase, and K+ channels." in: European journal of pharmacology, Vol. 740, pp. 112-20, (2014) (PubMed).

Geillinger, Rathmann, Köhrle, Fiamoncini, Daniel, Kipp: "Hepatic metabolite profiles in mice with a suboptimal selenium status." in: The Journal of nutritional biochemistry, Vol. 25, Issue 9, pp. 914-22, (2014) (PubMed).

Porteus, Abdallah, Pollack, Kumai, Kwong, Yew, Milsom, Perry: "The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio)." in: The Journal of physiology, Vol. 592, Issue 14, pp. 3075-88, (2014) (PubMed).

Dahlhoff, Worsch, Sailer, Hummel, Fiamoncini, Uebel, Obeid, Scherling, Geisel, Bader, Daniel: "Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels." in: Molecular metabolism, Vol. 3, Issue 5, pp. 565-80, (2014) (PubMed).

Fernandes, Ribeiro, Martínez, Orensanz, Barahona, Martínez-Sáenz, Recio, Benedito, Bustamante, Carballido, García-Sacristán, Prieto, Hernández: "Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck." in: The Journal of urology, Vol. 189, Issue 4, pp. 1567-73, (2013) (PubMed).

Markand, Tawfik, Ha, Gnana-Prakasam, Sonne, Ganapathy, Sen, Xian, Smith: "Cystathionine beta synthase expression in mouse retina." in: Current eye research, Vol. 38, Issue 5, pp. 597-604, (2013) (PubMed).

Dahlhoff, Desmarchelier, Sailer, Fürst, Haag, Ulbrich, Hummel, Obeid, Geisel, Bader, Daniel: "Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism." in: PLoS ONE, Vol. 8, Issue 3, pp. e57387, (2013) (PubMed).

Spellman, Ahmed, Dubach, Gardiner: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, (2012) (PubMed).

Details zu CBS

Target: CBS (Cystathionine-beta-Synthase (CBS))

Andere Bezeichnung: CBS (CBS Produkte)

Synonyme: hip4 antikoerper, GB12529 antikoerper, CBS antikoerper, DDBDRAFT_0189727 antikoerper, DDBDRAFT_0191292 antikoerper, DDB_0189727 antikoerper, DDB_0191292 antikoerper, cbs antikoerper, AI047524 antikoerper, AI303044 antikoerper, HIP4 antikoerper, cb442 antikoerper, wu:fb37g05 antikoerper, wu:fm61c07 antikoerper, wu:fq06c06 antikoerper, zgc:113704 antikoerper, cystathionine-beta-synthase L homeolog antikoerper, cystathionine-beta-synthase antikoerper, cystathionine beta-synthase antikoerper, cystathionine beta-synthase CBS antikoerper, cystathionine beta synthase antikoerper, cystathionine-beta-synthase S homeolog antikoerper, cystathionine-beta-synthase b antikoerper, cbs.L antikoerper, cbs antikoerper, Cbs antikoerper, CBS antikoerper, CNA06170 antikoerper, Tb11.02.5400 antikoerper, cysB antikoerper, LOC100635325 antikoerper, cbs.S antikoerper, cbsb antikoerper

Hintergrund: CBS is involved in the transsulfuration pathway. The first step of this pathway, from homocysteine to cystathionine, is catalyzed by this protein. CBS deficiency can cause homocystinuria which affects many organs and tissues, including the eyes and the skeletal, vascular and central nervous systems.The protein encoded by this gene is involved in the transsulfuration pathway. The first step of this pathway, from homocysteine to cystathionine, is catalyzed by this protein. CBS deficiency can cause homocystinuria which affects many organs and tissues, including the eyes and the skeletal, vascular and central nervous systems.
Alias Symbols: HIP4
Protein Interaction Partner: UBASH3A, UBE2I, PSMA1, PRKAG1, PIN1, EHHADH, CBS, SUMO1, UBC, NEDD8, PIAS3, RANBP9, PIAS1, CBX4, SRP14, RAD23B, PKM, NUCB1, IREB2, HSF1, LRSAM1, C14orf142, UBA5, IPO4, GOPC, PARP6, NPLOC4, DERA, ERO1L, DBNL, GPN1, PDLIM5, PLIN3, UBA2, GPSM1, COL4A3BP, UGP
Protein Size: 551

Molekulargewicht: 60 kDa

Gen-ID: 875

NCBI Accession: NM_000071, NP_000062

UniProt: P35520