BCL11A Antikörper (N-Term)

Produktnummer ABIN2781048

Produktdetails anti-BCL11A Antikörper

Target: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Schwein, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL11A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: MSRRKQGKPQ HLSKREFSPE PLEAILTDDE PDHGPLGAPE GDHDLLTCGQ

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against BCL11A. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human BCL11A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 835 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-BCL11A Antikörper (ABIN2781048)

Uda, Galanello, Sanna, Lettre, Sankaran, Chen, Usala, Busonero, Maschio, Albai, Piras, Sestu, Lai, Dei, Mulas, Crisponi, Naitza, Asunis, Deiana, Nagaraja, Perseu, Satta, Cipollina, Sollaino, Moi, Hirschhorn, Orkin, Abecasis, Schlessinger, Cao: "Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 5, pp. 1620-5, (2008) (PubMed).

Details zu BCL11A

Target: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Andere Bezeichnung: BCL11A (BCL11A Produkte)

Synonyme: 2810047E18Rik antikoerper, BCL-11A antikoerper, Ctip1 antikoerper, D930021L15Rik antikoerper, Evi9 antikoerper, Evi9a antikoerper, Evi9b antikoerper, Evi9c antikoerper, mKIAA1809 antikoerper, BCL11A-L antikoerper, BCL11A-S antikoerper, BCL11A-XL antikoerper, BCL11a-M antikoerper, CTIP1 antikoerper, EVI9 antikoerper, HBFQTL5 antikoerper, ZNF856 antikoerper, bcl11a antikoerper, wu:fi09f10 antikoerper, zgc:136898 antikoerper, B cell CLL/lymphoma 11A (zinc finger protein) antikoerper, B-cell CLL/lymphoma 11A antikoerper, B-cell CLL/lymphoma 11A L homeolog antikoerper, B-cell CLL/lymphoma 11Aa antikoerper, Bcl11a antikoerper, BCL11A antikoerper, bcl11a.L antikoerper, bcl11aa antikoerper

Hintergrund: BCL11A Is a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression.This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, FLJ10173, FLJ34997, HBFQTL5, KIAA1809, ZNF856
Protein Interaction Partner: GMCL1P1, ZBTB24, NCK2, LMO1, NR2E3, NR2E1, NR2F2, NR2F1, NR2F6, HDAC2, HDAC1, CDCA3, YME1L1, CDK6, CDK4, ACTC1, APP, UBC, BCL6, BCL11A, Sumo1, SUMO2, SUMO3, SIRT1, MBD3, MTA2, MTA1, CHD4,
Protein Size: 835

Molekulargewicht: 91 kDa

Gen-ID: 53335

NCBI Accession: NM_022893, NP_075044

UniProt: Q9H165

Pathways: Regulation of Cell Size