NR4A2 Antikörper (N-Term)

Produktnummer ABIN2780752

Produktdetails anti-NR4A2 Antikörper

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR4A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NR4A2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NR4A2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 598 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NR4A2 Antikörper (ABIN2780752)

Brami-Cherrier, Anzalone, Ramos, Forne, Macciardi, Imhof, Borrelli: "Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits." in: Molecular psychiatry, Vol. 19, Issue 11, pp. 1193-200, (2014) (PubMed).

Details zu NR4A2

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Andere Bezeichnung: NR4A2 (NR4A2 Produkte)

Synonyme: nr41/42/43 antikoerper, Nr4a2 antikoerper, nurr1 antikoerper, not antikoerper, rnr1 antikoerper, hzf-3 antikoerper, tinur antikoerper, NGFI-B antikoerper, HZF-3 antikoerper, NOT antikoerper, NURR1 antikoerper, RNR1 antikoerper, TINUR antikoerper, Nurr1 antikoerper, RNR-1 antikoerper, TINOR antikoerper, ngf1b antikoerper, nr4a2 antikoerper, zgc:92696 antikoerper, nuclear receptor subfamily 4 group A member 2 antikoerper, nuclear receptor antikoerper, nuclear receptor subfamily 4, group A, member 2 antikoerper, nuclear receptor subfamily 4, group A, member 2b antikoerper, NR4A2 antikoerper, nr41/42/43 antikoerper, nr4a2 antikoerper, Nr4a2 antikoerper, nr4a2b antikoerper

Hintergrund: NR4A2 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. The protein may act as a transcription factor. Mutations in NR4A2 gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of NR4A2 gene may be associated with rheumatoid arthritis.This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HZF-3, NOT, NURR1, RNR1, TINUR
Protein Interaction Partner: CDKN2D, TCEAL5, BAZ1B, ELAVL1, COPS5, RXRB, RXRA, RUNX1, SMARCA4, SMARCA2, SIN3A, NCOR2, SFPQ, PIAS4, RPS6KA1, CDKN1C, RARB, RARA, CREB1,
Protein Size: 598

Molekulargewicht: 66 kDa

Gen-ID: 4929

NCBI Accession: NM_006186, NP_006177

UniProt: P43354

Pathways: Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway