NR1D2 Antikörper (N-Term)

Produktnummer ABIN2780649

Produktdetails anti-NR1D2 Antikörper

Target: NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Kaninchen, Rind (Kuh), Hund, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR1D2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: YISSSSSASS HASCHSEGSE NSFQSSSSSV PSSPNSSNSD TNGNPKNGDL

Homologie: Cow: 79%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against NR1D2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NR1D2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 579 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NR1D2

Target: NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))

Andere Bezeichnung: NR1D2 (NR1D2 Produkte)

Synonyme: BD73 antikoerper, EAR-1R antikoerper, RVR antikoerper, HZF-2 antikoerper, Rev-erb antikoerper, REV-ERBB antikoerper, NR1D2 antikoerper, rvr antikoerper, bd73 antikoerper, hzf2 antikoerper, ear-1r antikoerper, hs.37288 antikoerper, NR1D2-A antikoerper, Reverbbeta-A antikoerper, reverbb1 antikoerper, reverbb antikoerper, reverbb2 antikoerper, zgc:92019 antikoerper, nuclear receptor subfamily 1 group D member 2 antikoerper, nuclear receptor subfamily 1, group D, member 2 antikoerper, nuclear receptor subfamily 1, group D, member 2a antikoerper, nuclear receptor subfamily 1, group D, member 2b antikoerper, NR1D2 antikoerper, Nr1d2 antikoerper, nr1d2 antikoerper, nr1d2a antikoerper, nr1d2b antikoerper

Hintergrund: NR1D2 can interact with NCOA5 coactivator, leading to a strong increase of transcription of target genes. NR1D2 also binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3' and acts as a potent competitive transcriptional silencer and negative regulator of RORalpha mediated trans-activation. NR1D2 may play different roles in metabolism, inflammation, and circadian cycling in the organ-specific manner in homeostasis.
Alias Symbols: BD73, EAR-1r, HZF2, Hs.37288, RVR, EAR-1R
Protein Interaction Partner: MID2, RBPMS, TRIM27, NOTCH2NL, KRTAP10-9, KRT40, KRTAP4-2, PRMT6, SKP1, UBC, SIN3B, KAT5, NCOR1, TAF9, TAF6, HDAC1, GTF2B, NCOA5, UBE2I, CUL1, NR1D1, RGN,
Protein Size: 579

Molekulargewicht: 65 kDa

Gen-ID: 9975

NCBI Accession: NM_005126, NP_005117

UniProt: Q14995

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway