SPI1 Antikörper (Middle Region)

Produktnummer ABIN2780474

Produktdetails anti-SPI1 Antikörper

Target: SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene Spi1 (SPI1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Pferd, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QKGNRKKMTY QKMARALRNY GKTGEVKKVK KKLTYQFSGE VLGRGGLAER

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SPI1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SPI1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 270 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SPI1

Target: SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene Spi1 (SPI1))

Andere Bezeichnung: SPI1 (SPI1 Produkte)

Synonyme: OF antikoerper, PU.1 antikoerper, SFPI1 antikoerper, SPI-1 antikoerper, SPI-A antikoerper, Dis-1 antikoerper, Dis1 antikoerper, Sfpi-1 antikoerper, Sfpi1 antikoerper, Spi-1 antikoerper, Tcfpu1 antikoerper, Tfpu.1 antikoerper, Pu.1 antikoerper, cb1086 antikoerper, pu.1 antikoerper, pu1 antikoerper, sfpi1 antikoerper, si:by184l24.2 antikoerper, spi1 antikoerper, SPI1/PU.1 antikoerper, spi1l antikoerper, zgc:152991 antikoerper, Spi-1 proto-oncogene antikoerper, spleen focus forming virus (SFFV) proviral integration oncogene antikoerper, Spi-1 proto-oncogene b antikoerper, Spi-1 proto-oncogene a antikoerper, SPI1 antikoerper, Spi1 antikoerper, spi1b antikoerper, spi1a antikoerper

Hintergrund: SPI1 is known to collaborate with multiple transcription factors and to regulate expression of immunoglobulin genes. Lack of SPI1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: OF, PU.1, SFPI1, SPI-1, SPI-A
Protein Interaction Partner: HOXA10, TMX1, VAV1, IRF1, IRF8, GATA3, GATA2, GATA1, GFI1, TBP, RB1, BYRF1, RARA, PML, HDAC3, SKI, SIN3A, HDAC1, BCL6, CEBPA, PIP, SPIB, SSRP1, IRF4, KAT6A, CEBPE, NFATC1, CREBBP, NONO, CEBPB, JUN, ERG, NFKB1, MITF, FUS, CREM, ATF1, CEBPD, MECP2, DNMT3B,
Protein Size: 270

Molekulargewicht: 31 kDa

Gen-ID: 6688

NCBI Accession: NM_003120, NP_003111

UniProt: P17947

Pathways: Stem Cell Maintenance