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PML Antikörper (N-Term)

PML Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2780446
  • Target Alle PML Antikörper anzeigen
    PML (Promyelocytic Leukemia (PML))
    Bindungsspezifität
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 57
    • 9
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 48
    • 11
    • 1
    Kaninchen
    Klonalität
    • 47
    • 13
    Polyklonal
    Konjugat
    • 43
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PML Antikörper ist unkonjugiert
    Applikation
    • 50
    • 27
    • 18
    • 16
    • 10
    • 9
    • 8
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    PSPSPSPTER APASEEEFQF LRCQQCQAEA KCPKLLPCLH TLCSGCLEAS
    Spezifität
    Isoform 1-14 specific
    Homologie
    Human: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against PML. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PML
    Top Product
    Discover our top product PML Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 435 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PML (Promyelocytic Leukemia (PML))
    Andere Bezeichnung
    PML (PML Produkte)
    Synonyme
    MYL antikoerper, PP8675 antikoerper, RNF71 antikoerper, TRIM19 antikoerper, 1200009E24Rik antikoerper, AI661194 antikoerper, Trim19 antikoerper, RGD1562602 antikoerper, PML antikoerper, promyelocytic leukemia antikoerper, PML antikoerper, Pml antikoerper
    Hintergrund
    PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
    Alias Symbols: MYL, PP8675, RNF71, TRIM19
    Protein Interaction Partner: RPL11, RPL5, SUMO1, UBC, TP53, SUMO2, SUMO3, MDM2, RNF4, EGFR, NCOA2, SP100, DAXX, MAPK7, HDAC1, ATXN1, ATRX, ASF1A, EHMT2, HIRA, HTT, H3F3A, ATF7IP, PML, JAK1, EIF4E, GLIS2, UBE2I, smt3, HDAC11, HDAC6, LMNA, RNF111, CDK6, CDK2, CDK1, CASP8AP2, RBX1, SH3G
    Protein Size: 435
    Molekulargewicht
    48 kDa
    Gen-ID
    5371
    NCBI Accession
    NM_033247, NP_150250
    UniProt
    P29590
    Pathways
    p53 Signalweg, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
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