MDC1 Antikörper (C-Term)

Produktnummer ABIN2779807

Produktdetails anti-MDC1 Antikörper

Target: MDC1 (Mdc1 (MDC1))

Bindungsspezifität: C-Term

Reaktivität: Human, Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MDC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GKEEDVVTPK PGKRKRDQAE EEPNRIPSRS LRRTKLNQES TAPKVLFTGV

Homologie: Dog: 86%, Guinea Pig: 92%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MDC1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MDC1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 2089 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MDC1

Target: MDC1 (Mdc1 (MDC1))

Andere Bezeichnung: MDC1 (MDC1 Produkte)

Synonyme: 6820401C03 antikoerper, AA413496 antikoerper, Nfbd1 antikoerper, mKIAA0170 antikoerper, NFBD1 antikoerper, mediator of DNA damage checkpoint 1 antikoerper, mediator of DNA-damage checkpoint 1 antikoerper, Mdc1 antikoerper, MDC1 antikoerper

Hintergrund: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Alias Symbols: DKFZp781A0122, KIAA0170, MGC166888, NFBD1
Protein Interaction Partner: RPA3, RPA2, RPA1, EED, TOPBP1, RNF8, UBC, LMNA, RAG1, CDC27, NCL, NBN, MRE11A, CSNK2A1, RAD50, CAPZB, CAPZA1, AUP1, ATP2A2, LOC729324, CHAMP1, HNRNPUL2, PGAM5, LSM12, ANAPC16, OSBPL8, DTX2, ZNF251, RBM17, FAM175A, LAS1L, LPCAT1, MYH14, SLC25A22, ZNF768, H
Protein Size: 2089

Molekulargewicht: 227 kDa

Gen-ID: 9656

NCBI Accession: NM_014641, NP_055456

UniProt: Q14676