SMAD6 Antikörper (N-Term)

Produktnummer ABIN2779804

Produktdetails anti-SMAD6 Antikörper

Target: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: APRDASDPLA GAALEPAGGG RSREARSRLL LLEQELKTVT YSLLKR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 91%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against SMAD6. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 496 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SMAD6

Target: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Andere Bezeichnung: SMAD6 (SMAD6 Produkte)

Synonyme: madh6 antikoerper, madh7 antikoerper, Xsmad6 antikoerper, hst17432 antikoerper, AOVD2 antikoerper, HsT17432 antikoerper, MADH6 antikoerper, MADH7 antikoerper, Madh6 antikoerper, b2b390Clo antikoerper, Smad6-like antikoerper, smad6 antikoerper, wu:fb22g05 antikoerper, SMAD family member 6 antikoerper, SMAD family member 6a antikoerper, smad6 antikoerper, SMAD6 antikoerper, Smad6 antikoerper, smad6a antikoerper

Hintergrund: SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.
Alias Symbols: MADH6, MADH7, HsT17432
Protein Interaction Partner: ITCH, SMURF2, BPIFA1, NEDD4L, WWP2, WWP1, USP15, USP11, PIGR, NASP, LYZ, KPNA2, CTBP2, CTBP1, UBC, ACVR1, UBE2O, BAMBI, STAMBP, ACTR1B, TGFBR1, MYD88, SMAD1, BMPR2, BMPR1B, BMPR1A, ACVR2B, ACVR1B, SMURF1, PELI1, CUL2, ELAVL1, SMAD5, RPS6KA5, TSC22D1, MAPK
Protein Size: 496

Molekulargewicht: 53 kDa

Gen-ID: 4091

NCBI Accession: NM_005585, NP_005576

UniProt: O43541

Pathways: Chromatin Binding