SMAD6 Antikörper (C-Term)
-
- Target Alle SMAD6 Antikörper anzeigen
- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
-
Bindungsspezifität
- C-Term
-
Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Kaninchen
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser SMAD6 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Sequenz
- PDGVWAYNRG EHPIFVNSPT LDAPGGRALV VRKVPPGYSI KVFDFERSGL
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
- Produktmerkmale
- This is a rabbit polyclonal antibody against Smad6. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of MOUSE Smad6
- Top Product
- Discover our top product SMAD6 Primärantikörper
-
-
- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeat freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
- Andere Bezeichnung
- Smad6 (SMAD6 Produkte)
- Synonyme
- madh6 antikoerper, madh7 antikoerper, Xsmad6 antikoerper, hst17432 antikoerper, AOVD2 antikoerper, HsT17432 antikoerper, MADH6 antikoerper, MADH7 antikoerper, Madh6 antikoerper, b2b390Clo antikoerper, Smad6-like antikoerper, smad6 antikoerper, wu:fb22g05 antikoerper, SMAD family member 6 antikoerper, SMAD family member 6a antikoerper, smad6 antikoerper, SMAD6 antikoerper, Smad6 antikoerper, smad6a antikoerper
- Hintergrund
-
Smad6 binds to regulatory elements in target promoter regions. It may block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. It acts as a mediator of TGF-beta and BMP antiflammatory activity. It suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.
Protein Interaction Partner: Smurf1, Tbx6, Bmpr2, Bmpr1a, Acvr1, Runx2, tob1a, Axin1, SMURF2, BMPR1B,
Protein Size: 459 - Molekulargewicht
- 54 kDa
- Gen-ID
- 17130
- UniProt
- O35182
- Pathways
- Chromatin Binding
-