SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) Antikörper

Details zu Produkt Nr. ABIN2779689, Anbieter: Anmelden zum Anzeigen
Antigen
  • 2610028O16Rik
  • AI195385
  • AU016842
  • AW536442
  • D11Ertd530e
  • mKIAA0160
  • SUZ12 polycomb repressive complex 2 subunit
  • suppressor of zeste 12 homolog (Drosophila)
  • Suz12
Epitop
Middle Region
7
5
4
3
2
2
2
2
2
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
78
34
6
5
3
3
3
2
2
1
1
1
Wirt
Kaninchen
49
34
Klonalität
Polyklonal
Applikation
Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC), Western Blotting (WB)
78
43
21
9
8
8
8
3
3
3
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human SUZ12
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN984652.
Sequenz TGETNDKSTA PIAKPLATRN SESLHQENKP GSVKPTQTIA VKESLTTDLQ
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against SUZ12. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung SUZ12 (SUZ12 Antibody Abstract)
Hintergrund A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t (7,17)(p15,q21) with JAZF1 generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CHET9, JJAZ1, KIAA0160
Protein Interaction Partner: FBXW11, EZH2, BRCA1, CDK5RAP2, RBM22, LUC7L, NHP2, H2AFY2, C17orf85, NAT10, ATAD3A, HEATR1, PTCD3, CHCHD3, CDKAL1, DDX56, GDAP1, LUC7L3, SF3B6, LUC7L2, NOP58, LIMA1, CDC40, CRNKL1, HP1BP3, STOML2, TRA2A, RBM15B, REPIN1, PRPF19, AKAP8L, TBL2, DAZAP1, PHGDH
Protein Size: 739
Molekulargewicht 83 kDa
Gen-ID 23512
NCBI Accession NM_015355, NP_056170
UniProt Q15022
Forschungsgebiet Chromatin and Nuclear Signaling, Transcription Factors
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 739 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) antibody (ABIN2779689) anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) antibody
Chromatin Immunoprecipitation (ChIP) image for anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) antibody (ABIN2779689) Chromatin Immunoprecipitation (ChIP) Using SUZ12 Antibody - middle region (ARP32515_P...
Allgemeine Veröffentlichungen Li, Ma, Wang, Koontz, Nucci, Sklar: "Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 50, pp. 20001-6, 2007 (PubMed).

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