SIRT6 Antikörper (Middle Region)

Produktnummer ABIN2779624

Produktdetails anti-SIRT6 Antikörper

Target: SIRT6 (Sirtuin 6 (SIRT6))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Hund, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)

Sequenz: TRINGSIPAG PKQEPCAQHN GSEPASPKRE RPTSPAPHRP PKRVKAKAVP

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Rat: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against SIRT6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SIRT6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 355 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SIRT6 Antikörper (ABIN2779624)

Wajapeyee, Malonia, Palakurthy, Green: "Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors." in: Genes & development, Vol. 27, Issue 20, pp. 2221-6, (2013) (PubMed).

Gazin, Wajapeyee, Gobeil, Virbasius, Green: "An elaborate pathway required for Ras-mediated epigenetic silencing." in: Nature, Vol. 449, Issue 7165, pp. 1073-7, (2007) (PubMed).

Details zu SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Andere Bezeichnung: SIRT6 (SIRT6 Produkte)

Hintergrund: SIRT6 is a NAD-dependent protein deacetylase. SIRT6 has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. SIRT6 is required for genomic stability, normal IGF1 serum levels and normal glucose homeostasis. SIRT6 modulates cellular senescence and apoptosis. SIRT6 regulates the production of TNF protein.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Alias Symbols: SIR2L6
Protein Interaction Partner: UBC, MDM2, AKT1, STUB1, SKP2, ABCF2, FAF1, VIM, UBE2D1, CHD3, NR0B2, tat, CCNDBP1, RELA, XRCC5, PRKDC, XRCC6, ELF5,
Protein Size: 355

Molekulargewicht: 39 kDa

Gen-ID: 51548

NCBI Accession: NM_016539, NP_057623

UniProt: Q8N6T7