SMAD5 Antikörper (SMAD, Mothers Against DPP Homolog 5) (Middle Region)

Details for Product anti-SMAD5 Antibody No. ABIN2779414, Anbieter: Anmelden zum Anzeigen
Antigen
  • SBN
  • fb67b04
  • mad
  • madh5
  • sb:cb400
  • smd5
  • wu:fb67b04
  • XSmad4alpha
  • dpc4
  • jip
  • jv5-1
  • madh4
  • smad10
  • smad5
  • xsmad4
  • DWFC
  • JV5-1
  • MADH5
  • 1110051M15Rik
  • AI451355
  • Dwf-C
  • Madh5
  • MusMLP
  • SMAD5
  • DKFZp468M0619
  • SMAD family member 5
  • MAD homolog 5 (Drosophila)
  • SMAD family member 4, gene 2
  • SMAD5
  • smad5
  • smad4.2-b
  • Smad5
Epitop
Middle Region
20
16
12
10
5
4
3
3
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Schaf, Zebrafisch
108
47
38
7
6
6
5
4
4
3
3
2
1
1
Wirt
Kaninchen
70
39
1
Klonalität
Polyklonal
Konjugat
Dieser SMAD5 Antikörper ist unkonjugiert
3
3
3
3
3
3
Applikation
Western Blotting (WB)
105
57
29
25
19
18
10
3
2
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human SMAD5
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN984103.
Sequenz YPPSPASSTY PNSPASSGPG SPFQLPADTP PPAYMPPDDQ MGQDNSQPMD
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%, Zebrafish: 93%
Produktmerkmale This is a rabbit polyclonal antibody against SMAD5. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung SMAD5 (SMAD5 Antibody Abstract)
Hintergrund SMAD5 undergoes copy number gain and increased expression, rather than loss of expression, and therefore does not act as a tumor-suppressor gene in hepatocellular carcinoma. Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by Helicobacter pylori infection.
Alias Symbols: DWFC, JV5-1, MADH5
Protein Interaction Partner: UBC, SUMO1, HECW2, HBG2, BCAT1, SOX5, SNRPA, SNRNP70, SFPQ, RYR2, RBM4, PTPN12, PSMD11, NEDD4, SMAD4, SMAD1, ANKRD13A, PPIL4, SOX7, SMURF2, SMURF1, MTMR10, CHMP3, CXXC5, SF3B1, U2AF2, PNKP, WWP1, NAA20, EPN1, SMAD3, SMAD2, PAX6, COPS5, HGS, EP300, ELAVL1,
Protein Size: 465
Molekulargewicht 51 kDa
Gen-ID 4090
NCBI Accession NM_005903, NP_005894
UniProt Q99717
Forschungsgebiet Organogenesis, Signaling, Transcription Factors
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 465 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-SMAD, Mothers Against DPP Homolog 5 (SMAD5) (Middle Region) antibody (ABIN2779414) WB Suggested Anti-SMAD5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Western Blotting (WB) image for anti-SMAD, Mothers Against DPP Homolog 5 (SMAD5) (Middle Region) antibody (ABIN2779414) WB Suggested Anti-SMAD5
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <...
Allgemeine Veröffentlichungen Zimonjic, Durkin, Keck-Waggoner, Park, Thorgeirsson, Popescu: "SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma." in: Neoplasia (New York, N.Y.), Vol. 5, Issue 5, pp. 390-6, 2003 (PubMed).

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