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MAP3K8 Antikörper (C-Term)

MAP3K8 Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2779365
  • Target Alle MAP3K8 Antikörper anzeigen
    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
    Bindungsspezifität
    • 19
    • 12
    • 10
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 88
    • 40
    • 38
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Ratte, Maus, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen
    Wirt
    • 87
    • 1
    Kaninchen
    Klonalität
    • 87
    • 1
    Polyklonal
    Konjugat
    • 39
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAP3K8 Antikörper ist unkonjugiert
    Applikation
    • 54
    • 41
    • 30
    • 18
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    PRCQSLDSAL LERKRLLSRK ELELPENIAD SSCTGSTEES EMLKRQRSLY
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 77%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against MAP3K8. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human MAP3K8
    Top Product
    Discover our top product MAP3K8 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 467 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
    Andere Bezeichnung
    MAP3K8 (MAP3K8 Produkte)
    Synonyme
    MAP3K8 antikoerper, COT antikoerper, EST antikoerper, ESTF antikoerper, MEKK8 antikoerper, TPL2 antikoerper, Tpl-2 antikoerper, c-COT antikoerper, Cot antikoerper, Cot/Tpl2 antikoerper, Est antikoerper, Estf antikoerper, Tpl2 antikoerper, D17TPL2 antikoerper, mitogen-activated protein kinase kinase kinase 8 antikoerper, MAP3K8 antikoerper, map3k8 antikoerper, Map3k8 antikoerper
    Hintergrund
    MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.
    Alias Symbols: COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT
    Protein Interaction Partner: RELA, MAP2K1, RIPK1, NFKB1, ACY3, STIP1, HSP90AA1, TAB2, TRAF6, TRAF2, CD40, TNIP2, Nedd4, MAP3K14, MAP2K4, BMPR2, CHUK, REL, AKT1, NFKB2, KSR2,
    Protein Size: 467
    Molekulargewicht
    53 kDa
    Gen-ID
    1326
    NCBI Accession
    NM_005204, NP_005195
    UniProt
    P41279
    Pathways
    PI3K-Akt Signalweg, T-Zell Rezeptor Signalweg
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