MAP3K8 Antikörper (C-Term)
-
- Target Alle MAP3K8 Antikörper anzeigen
- MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
-
Bindungsspezifität
- C-Term
-
Reaktivität
- Human, Ratte, Maus, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser MAP3K8 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Sequenz
- PRCQSLDSAL LERKRLLSRK ELELPENIAD SSCTGSTEES EMLKRQRSLY
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 77%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against MAP3K8. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human MAP3K8
- Top Product
- Discover our top product MAP3K8 Primärantikörper
-
-
- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
-
Antigen size: 467 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
- Andere Bezeichnung
- MAP3K8 (MAP3K8 Produkte)
- Synonyme
- MAP3K8 antikoerper, COT antikoerper, EST antikoerper, ESTF antikoerper, MEKK8 antikoerper, TPL2 antikoerper, Tpl-2 antikoerper, c-COT antikoerper, Cot antikoerper, Cot/Tpl2 antikoerper, Est antikoerper, Estf antikoerper, Tpl2 antikoerper, D17TPL2 antikoerper, mitogen-activated protein kinase kinase kinase 8 antikoerper, MAP3K8 antikoerper, map3k8 antikoerper, Map3k8 antikoerper
- Hintergrund
-
MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.
Alias Symbols: COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT
Protein Interaction Partner: RELA, MAP2K1, RIPK1, NFKB1, ACY3, STIP1, HSP90AA1, TAB2, TRAF6, TRAF2, CD40, TNIP2, Nedd4, MAP3K14, MAP2K4, BMPR2, CHUK, REL, AKT1, NFKB2, KSR2,
Protein Size: 467 - Molekulargewicht
- 53 kDa
- Gen-ID
- 1326
- NCBI Accession
- NM_005204, NP_005195
- UniProt
- P41279
- Pathways
- PI3K-Akt Signalweg, T-Zell Rezeptor Signalweg
-