RAD17 Antikörper (N-Term)

Produktnummer ABIN2779342

Produktdetails anti-RAD17 Antikörper

Target: RAD17

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Hund, Rind (Kuh), Schwein, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MNQVTDWVDP SFDDFLECSG VSTITATSLG VNNSSHRRKN GPSTLESSRF

Homologie: Cow: 89%, Dog: 100%, Horse: 92%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 89%

Produktmerkmale: This is a rabbit polyclonal antibody against RAD17. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RAD17

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 670 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RAD17

Target: RAD17

Andere Bezeichnung: RAD17 (RAD17 Produkte)

Synonyme: zgc:91969 antikoerper, RAD17 antikoerper, K2A18.21 antikoerper, K2A18_21 antikoerper, RADIATION SENSITIVE 17 antikoerper, CCYC antikoerper, HRAD17 antikoerper, R24L antikoerper, RAD17SP antikoerper, RAD24 antikoerper, 9430035O09Rik antikoerper, MmRad24 antikoerper, RAD17 checkpoint clamp loader component antikoerper, Rad17p antikoerper, RADIATION SENSITIVE 17 antikoerper, RAD17 antikoerper, rad17 antikoerper, ATRAD17 antikoerper, Rad17 antikoerper

Hintergrund: RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation.
Alias Symbols: CCYC, FLJ41520, HRAD17, R24L, RAD17SP, RAD24
Protein Interaction Partner: USP20, UBC, PRMT6, CBX7, CBX6, RAD9A, CDH1, ATR, RFC1, H2AFX, FOXO3, ATM, CLSPN, ALK, RAD9B, POLE, HUS1, RAD1, NHP2L1, MCM7, RFC4, RFC5, RFC3, RFC2, POLE4, POLE3, POLE2, PRKDC,
Protein Size: 670

Molekulargewicht: 76 kDa

Gen-ID: 5884

NCBI Accession: NM_002873, NP_002864