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p21 Antikörper (N-Term)
CDKN1A
Reaktivität: Human, Maus, Ratte, Schaf, Rind (Kuh), Hund, Schwein, Meerschweinchen, Pferd, Kaninchen
WB, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2779298
Produktdetails anti-p21 Antikörper
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Target
Alle p21 (CDKN1A) Antikörper anzeigen
p21 (CDKN1A)
(Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
Bindungsspezifität
Alle Epitope für p21 Antikörper
N-Term
Reaktivität
Alle Reaktivitäten für p21 Antikörper
Human, Maus, Ratte, Schaf, Rind (Kuh), Hund, Schwein, Meerschweinchen, Pferd, Kaninchen
Wirt
Alle Wirte für p21 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für p21 Antikörper
Polyklonal
Konjugat
Alle Konjugate für p21 Antikörper
Dieser p21 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für p21 Antikörper
Western Blotting (WB), Immunohistochemistry (IHC)
Sequenz
KACRRLFGPV DSEQLSRDCD ALMAGCIQEA RERWNFDFVT ETPLEGDFAW
Homologie
Cow: 100%, Dog: 92%, Guinea Pig: 92%, Horse: 83%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 92%, Rat: 100%, Sheep: 100%
Produktmerkmale
This is a rabbit polyclonal antibody against CDKN1A. It was validated on Western Blot.
Aufreinigung
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human CDKN1A
Top Product
Discover our top product CDKN1A Primärantikörper
Alternativen
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anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 21-100) antibody
CDKN1A
Reaktivität: Human, Maus, Ratte, Schaf
WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Anwendungsinformationen
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Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeat freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Details zu p21
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Target
p21 (CDKN1A)
(Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
Andere Bezeichnung
CDKN1A (CDKN1A Produkte )
Synonyme
CCND1 antikoerper, CDKN1A antikoerper, CAP20 antikoerper, CDKN1 antikoerper, CIP1 antikoerper, MDA-6 antikoerper, P21 antikoerper, SDI1 antikoerper, WAF1 antikoerper, p21CIP1 antikoerper, CDKI antikoerper, Cdkn1 antikoerper, Waf1 antikoerper, mda6 antikoerper, p21Cip1 antikoerper, p21WAF antikoerper, Cip1 antikoerper, UV96 antikoerper, p21 antikoerper, cip1 antikoerper, p16Xic2 antikoerper, sdi1 antikoerper, waf1 antikoerper, cap20 antikoerper, cdkn1 antikoerper, mda-6 antikoerper, p21cip1 antikoerper, si:ch1073-48m5.2 antikoerper, KRAS2 antikoerper, p21ras antikoerper, cyclin D1 antikoerper, cyclin dependent kinase inhibitor 1A antikoerper, cyclin-dependent kinase inhibitor 1A (P21) antikoerper, cyclin-dependent kinase inhibitor 1A antikoerper, cyclin-dependent kinase inhibitor 1A L homeolog antikoerper, cyclin-dependent kinase inhibitor 1 antikoerper, KRAS proto-oncogene, GTPase antikoerper, CCND1 antikoerper, CDKN1A antikoerper, Cdkn1a antikoerper, cdkn1a.L antikoerper, cki1 antikoerper, cdkn1a antikoerper, KRAS antikoerper
Hintergrund
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. Alias Symbols: CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Protein Interaction Partner: CCND1, PCNA, KRT31, TRIM54, TEX11, IKZF3, UBC, TRAF1, TCF4, SKP2, CCND3, CCND2, PHKG2, PHKA1, NCL, HSPA9, HSPA8, HSPA5, HSPA2, HSPA1A, HNRNPA2B1, CDK2, CDK5, CDK4, CDK3, CDC20, CCNE1, CCNB1, CCNA2, CAMK2D, ABR, GIGYF2, ANKRD17, UBR4, SNRNP200, FBXO21, PUF Protein Size: 164
Molekulargewicht
18 kDa
Gen-ID
1026
NCBI Accession
NM_078467 , NP_510867
UniProt
Q6FI05
Pathways
p53 Signalweg , PI3K-Akt Signalweg , Zellzyklus , AMPK Signaling , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Mitotic G1-G1/S Phases , DNA Replication , Hepatitis C , Synthesis of DNA , Autophagie
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