PTBP1 Antikörper (Middle Region)
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- Target Alle PTBP1 Antikörper anzeigen
- PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PTBP1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- KGFKFFQKDR KMALIQMGSV EEAVQALIDL HNHDLGENHH LRVSFSKSTI
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against PTBP1. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PTBP1
- Top Product
- Discover our top product PTBP1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 557 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 1894-9, (2010) (PubMed).
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The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 1894-9, (2010) (PubMed).
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- Target
- PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))
- Andere Bezeichnung
- PTBP1 (PTBP1 Produkte)
- Synonyme
- HNRNP-I antikoerper, HNRNPI antikoerper, HNRPI antikoerper, PTB antikoerper, PTB-1 antikoerper, PTB-T antikoerper, PTB2 antikoerper, PTB3 antikoerper, PTB4 antikoerper, pPTB antikoerper, Ptb antikoerper, hnrpi antikoerper, hnrnp-I antikoerper, vgrbp60 antikoerper, AA407203 antikoerper, AL033359 antikoerper, Pybp antikoerper, Pybp1 antikoerper, Pybp2 antikoerper, ptbp1 antikoerper, wu:fb99f12 antikoerper, zgc:110689 antikoerper, ptb antikoerper, ATPTB1 antikoerper, POLYPYRIMIDINE TRACT-BINDING antikoerper, POLYPYRIMIDINE TRACT-BINDING PROTEIN 1 antikoerper, T4P13.16 antikoerper, T4P13_16 antikoerper, polypyrimidine tract-binding protein 1 antikoerper, PTBP1 antikoerper, polypyrimidine tract binding protein 1 antikoerper, polypyrimidine tract binding protein 1 S homeolog antikoerper, polypyrimidine tract-binding protein antikoerper, polypyrimidine tract binding protein 1a antikoerper, polypyrimidine tract binding protein 1 L homeolog antikoerper, polypyrimidine tract-binding protein 1 antikoerper, PTBP1 antikoerper, ptbp1.S antikoerper, NAEGRDRAFT_80143 antikoerper, LOC100285404 antikoerper, Ptbp1 antikoerper, ptbp1a antikoerper, ptbp1.L antikoerper, PTB1 antikoerper, LOC100061673 antikoerper
- Hintergrund
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PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
Alias Symbols: HNRNP-I, HNRNPI, HNRPI, MGC10830, MGC8461, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB
Protein Interaction Partner: UBC, SNRPA, SFPQ, PTBP1, NONO, LGR4, MDM2, RPA3, RPA2, RPA1, BMI1, SUZ12, EED, RNF2, DIMT1, YBX3, AIMP2, SPTAN1, RPS27, QARS, YBX1, RPSA, ILF2, HNRNPU, HNRNPD, HNRNPA2B1, FAU, EPRS, EIF4G1, APBB1, ABCF1, NELFB, G3BP1, AIMP1, EIF2B2, IQGAP1, TARDBP, SRPK2,
Protein Size: 557 - Molekulargewicht
- 60 kDa
- Gen-ID
- 5725
- NCBI Accession
- NM_002819, NP_002810
- UniProt
- Q29099
- Pathways
- Regulation of Muscle Cell Differentiation
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