MBD2 Antikörper (Middle Region)

Produktnummer ABIN2778640

Produktdetails anti-MBD2 Antikörper

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MBD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: DCPALPPGWK KEEVIRKSGL SAGKSDVYYF SPSGKKFRSK PQLARYLGNT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against MBD2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MBD2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 302 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MBD2

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Andere Bezeichnung: MBD2 (MBD2 Produkte)

Synonyme: MBD2 antikoerper, DMTase antikoerper, NY-CO-41 antikoerper, MBD2a antikoerper, wu:fa97f06 antikoerper, zgc:111862 antikoerper, methyl-CpG binding domain protein 2 antikoerper, methyl-CpG binding domain protein 2 S homeolog antikoerper, MBD2 antikoerper, Mbd2 antikoerper, mbd2 antikoerper, mbd2.S antikoerper

Hintergrund: MBD2 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD2 can also repress transcription from methylated gene promoters. MBD2 may function as a mediator of the biological consequences of the methylation signal.It is also reported that the MBD2 functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Alias Symbols: DMTase, NY-CO-41
Protein Interaction Partner: UBC, SOX2, HDAC2, HDAC1, MTA3, LAMTOR3, TFAP4, KDM5B, CDK2AP1, ESR1, KDM1A, MTA2, MBD2, RBBP7, RBBP4, CHD3, tat, MBD3L2, MBD3, csul, GATAD2A, TACC3, PRMT5, WDR77, PRMT1, PTK2B, TRIM27, GATAD2B, MBD3L1, GPN1, SIN3A, HINFP, DHX9, CREBBP, DNMT1, tax, NEWENTR
Protein Size: 302

Molekulargewicht: 32 kDa

Gen-ID: 8932

NCBI Accession: NM_015832, NP_056647

Pathways: Chromatin Binding