INSIG2 Antikörper (N-Term)

Produktnummer ABIN2778637

Produktdetails anti-INSIG2 Antikörper

Target: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Hund, Schwein, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INSIG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MAEGETESPG PKKCGPYISS VTSQSVNLMI RGVVLFFIGV FLALVLNLLQ

Homologie: Cow: 100%, Dog: 92%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 100%, Rat: 92%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against INSIG2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human INSIG2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 225 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-INSIG2 Antikörper (ABIN2778637)

Yu, Wang, Fok, Coles, Salmon, Pérez: "Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver." in: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 70, Issue 4, pp. 410-20, (2015) (PubMed).

Details zu INSIG2

Target: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Andere Bezeichnung: INSIG2 (INSIG2 Produkte)

Synonyme: MGC82156 antikoerper, INSIG-2 antikoerper, 2900053I11Rik antikoerper, C730043J18Rik antikoerper, Insig-2 antikoerper, insulin induced gene 2 antikoerper, insulin induced gene 2 L homeolog antikoerper, insig2 antikoerper, insig2.L antikoerper, INSIG2 antikoerper, Insig2 antikoerper

Hintergrund: INSIG2 is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC26273
Protein Interaction Partner: RNF5, HMGCR, SCAP, SREBF1, RNF139, UBQLN1, UBQLN2, FAF2, ADRM1, PSMD14, BAG6, VCP, UBC, RPN1, PSMD13, PSMD12, PSMD11, PSMD4, PSMC6, PSMC5, PSMC3, PSMC2, PSMB3, PSMB1, PSMA7, PSMA2, LGALS7, JUP, INSIG1, HSPA8, HSPA6, HSPA5, HSPA1A, ENO1, DSP, AMFR, SREBF2,
Protein Size: 225

Molekulargewicht: 25 kDa

Gen-ID: 51141

NCBI Accession: NM_016133, NP_057217

UniProt: Q9Y5U4

Pathways: ER-Nucleus Signaling