Claudin 16 Antikörper (C-Term)

Produktnummer ABIN2778049

Produktdetails anti-Claudin 16 Antikörper

Target: Claudin 16 (CLDN16)

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Schwein, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FLAGAVLTCC LYLFKDVGPE RNYPYSLRKA YSAAGVSMAK SYSAPRTETA

Homologie: Cow: 86%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 86%, Rabbit: 93%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against CLDN16. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN16

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 305 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Claudin 16 Antikörper (ABIN2778049)

Peng, Rao, Adelman, Rizzolo: "Claudin-19 and the barrier properties of the human retinal pigment epithelium." in: Investigative ophthalmology & visual science, Vol. 52, Issue 3, pp. 1392-403, (2011) (PubMed).

Wang, Zhang, Maminishkis, Dong, Zhi, Li, Zhao, Majerciak, Gaur, Chen, Miller: "MicroRNA-204/211 alters epithelial physiology." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 5, pp. 1552-71, (2010) (PubMed).

Details zu Claudin 16

Target: Claudin 16 (CLDN16)

Andere Bezeichnung: CLDN16 (CLDN16 Produkte)

Synonyme: CLDN16 antikoerper, HOMG3 antikoerper, PCLN1 antikoerper, claudin-16 antikoerper, Pcln1 antikoerper, claudin 16 antikoerper, CLDN16 antikoerper, Cldn16 antikoerper

Hintergrund: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-16, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in the corresponding gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HOMG3, PCLN1
Protein Interaction Partner: APP, TJP1,
Protein Size: 305

Molekulargewicht: 34 kDa

Gen-ID: 10686

NCBI Accession: NM_006580, NP_006571

UniProt: Q9Y5I7

Pathways: Hepatitis C