PURA Antikörper (Purine-Rich Element Binding Protein A) (N-Term)

Details for Product anti-PURA Antibody No. ABIN2777801, Anbieter: Anmelden zum Anzeigen
Antigen
  • CAGER-1
  • Pur-alpha
  • ssCRE-BP
  • PUR-ALPHA
  • PUR1
  • PURALPHA
  • zgc:103411
  • pur-alpha
  • pur1
  • puralpha
  • purine-rich element binding protein A
  • purine rich element binding protein A
  • pura
  • Pura
  • PURA
Epitop
N-Term
7
6
6
5
4
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human
41
21
18
9
9
9
8
7
4
4
4
2
2
1
Wirt
Kaninchen
27
16
Klonalität
Polyklonal
Applikation
Western Blotting (WB)
39
16
4
4
3
2
1
1
Optionen
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PURA
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN982476.
Sequenz MADRDSGSEQ GGAALGSGGS LGHPGSGSGS GGGGGGGGGG GGSGGGGGGA
Homologie Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%
Produktmerkmale This is a rabbit polyclonal antibody against PURA. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity purified
Andere Bezeichnung PURA (PURA Antibody Abstract)
Hintergrund This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
Alias Symbols: PUR1, MRD31, PURALPHA, PUR-ALPHA
Protein Interaction Partner: RAF1, UBC, LIN28B, LIN28A, BMI1, TARDBP, IGSF8, ICAM1, IL7R, ZNF638, DDX23, RFC3, RFC2, RB1, PURB, POLA1, CAND1, CUL1, CUL3, EIF2AK2, POU5F1, MEPCE, HNRNPA1, ADAP1, CCNT1, E2F1, SP1, YBX1, CDK5, CNBP, Jvgp5,
Protein Size: 322
Molekulargewicht 35 kDa
Gen-ID 5813
NCBI Accession NM_005859, NP_005850
UniProt Q00577
Forschungsgebiet Chromatin and Nuclear Signaling, Transcription Factors, Chromatin Binding Proteins, DNA/RNA
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 322 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-PURA Antikörper (Purine-Rich Element Binding Protein A) (N-Term) (ABIN2777801) anti-Purine-Rich Element Binding Protein A (PURA) (N-Term) antibody
Allgemeine Veröffentlichungen Wang, Johnson, Kinoshita, Babb, Buckley, Liebes, Melamed, Liu, Kurek, Ossowski, Ferrari: "Androgen receptor overexpression in prostate cancer linked to Pur alpha loss from a novel repressor complex." in: Cancer research, Vol. 68, Issue 8, pp. 2678-88, 2008 (PubMed).