APP Antikörper (Amyloid beta (A4) Precursor Protein) (Middle Region)

Details for Product anti-APP Antibody No. ABIN2777738, Anbieter: Anmelden zum Anzeigen
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
  • beta amyloid protein precursor-like
  • amyloid beta (A4) precursor protein
  • amyloid beta (A4) precursor protein a
  • beta amyloid protein precursor
  • Appl
  • APP
  • app
  • App
  • appa
  • LOC100009546
Epitop
Middle Region
107
107
72
39
37
32
31
19
17
15
15
14
14
13
12
10
9
7
7
7
7
7
6
5
5
5
5
5
5
5
5
5
5
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Zebrafisch
944
387
368
39
27
20
18
18
14
13
11
9
7
7
4
4
4
3
2
2
1
Wirt
Kaninchen
657
263
52
7
2
Klonalität
Polyklonal
Konjugat
Dieser APP Antikörper ist unkonjugiert
51
43
41
17
15
14
14
14
13
13
13
13
13
13
13
8
8
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
672
403
297
165
159
122
90
57
40
35
17
15
15
10
8
3
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human APP
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN973339.
Sequenz EAKHRERMSQ VMREWEEAER QAKNLPKADK KAVIQHFQEK VESLEQEAAN
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
Produktmerkmale This is a rabbit polyclonal antibody against APP. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung APP (APP Antibody Abstract)
Hintergrund APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, PN-II
Protein Size: 695
Molekulargewicht 77 kDa
Gen-ID 351
NCBI Accession NM_201414, NP_958817
UniProt P05067
Forschungsgebiet Signaling
Pathways Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 695 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Amyloid beta (A4) Precursor Protein (APP) (Middle Region) antibody (ABIN2777738) WB Suggested Anti-APP Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1...
Allgemeine Veröffentlichungen Locascio, Fukumoto, Yap, Bottiglieri, Growdon, Hyman, Irizarry: "Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease." in: Archives of neurology, Vol. 65, Issue 6, pp. 776-85, 2008 (PubMed).

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