PPARG Antikörper (N-Term)

Produktnummer ABIN2777644

Produktdetails anti-PPARG Antikörper

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Bindungsspezifität: N-Term

Reaktivität: Human, Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPARG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MGETLGDSPI DPESDSFTDT LSANISQEMT MVDTEMPFWP TNFGISSVDL

Homologie: Dog: 92%, Human: 100%, Pig: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against PPARG. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PPARG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 505 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PPARG

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Andere Bezeichnung: PPARG (PPARG Produkte)

Synonyme: PPAR gamma antikoerper, PPARg2 antikoerper, PPARG antikoerper, Nr1c3 antikoerper, PPAR-gamma antikoerper, PPAR-gamma2 antikoerper, PPARgamma antikoerper, PPARgamma2 antikoerper, NR1C3 antikoerper, CIMT1 antikoerper, GLM1 antikoerper, PPARG1 antikoerper, PPARG2 antikoerper, xPPAR-gamma antikoerper, PPAR-GAMMA antikoerper, PPARGAMMA antikoerper, peroxisome proliferator-activated receptor gamma antikoerper, peroxisome proliferator activated receptor gamma antikoerper, peroxisome proliferator activated receptor gamma L homeolog antikoerper, PPARG antikoerper, Pparg antikoerper, pparg.L antikoerper

Hintergrund: PPARG is a receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPARG is the key regulator of adipocyte differentiation and glucose homeostasis.This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
Alias Symbols: NR1C3, PPARG1, PPARG2, GLM1, CIMT1, PPARgamma
Protein Interaction Partner: HDAC3, NCOA1, NCOA3, SUMO1, UBC, SUMO2, RXRA, MED1, HMGA1, EP300, NCOA2, CDC34, PRKAA2, PRKAA1, PPARGC1A, ASH2L, RBBP5, NSD1, NCOA6, PAXIP1, MUC1, NR3C1, SMAD2, CREBBP, ALOX15B, ZFYVE9, USP7, NCOR1, CDK5, SMARCD3, SMARCA4, NEDD4, BCAS2, MIF4GD, MED14, JAZ
Protein Size: 505

Molekulargewicht: 57 kDa

Gen-ID: 5468

NCBI Accession: NM_015869, NP_056953

UniProt: P37231

Pathways: MAPK Signalweg, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation