FOXP3 Antikörper (N-Term)

Produktnummer ABIN2777561

Produktdetails anti-FOXP3 Antikörper

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Pferd, Kaninchen, Hund, Schaf, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: PHFMHQLSTV DAHARTPVLQ VHPLESPAMI SLTPPTTATG VFSLKARPGL

Homologie: Cow: 100%, Dog: 79%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 86%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against FOXP3. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FOXP3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 431 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FOXP3 Antikörper (ABIN2777561)

Kawabata, Ohta, Seiler, Pyle, Ishiguro, Zhang, Becker, Troyer, Tamura: "Naïve rat umbilical cord matrix stem cells significantly attenuate mammary tumor growth through modulation of endogenous immune responses." in: Cytotherapy, Vol. 15, Issue 5, pp. 586-97, (2013) (PubMed).

Takahata, Nomura, Takada, Ohga, Furuno, Hikino, Nakayama, Sakaguchi, Hara: "CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene." in: Experimental hematology, Vol. 32, Issue 7, pp. 622-9, (2004) (PubMed).

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: FOXP3 (FOXP3 Produkte)

Synonyme: foxp3 antikoerper, FOXP3 antikoerper, AIID antikoerper, DIETER antikoerper, IPEX antikoerper, PIDX antikoerper, XPID antikoerper, JM2 antikoerper, scurfin antikoerper, sf antikoerper, RGD1562112 antikoerper, forkhead box P3 antikoerper, forkhead box P3a antikoerper, forkhead box P3 L homeolog antikoerper, FOXP3 antikoerper, foxp3a antikoerper, foxp3 antikoerper, foxp3.L antikoerper, Foxp3 antikoerper

Hintergrund: Forkhead box protein P3 (FOXP3, Scurfin, Zinc finger protein JM2) encodes a novel member of the forkhead family of transcription factors. It presumably represses transcription, playing a paramount role in determining the amplitude of the response of CD4 T cells to activation
Alias Symbols: JM2, AIID, IPEX, PIDX, XPID, DIETER
Protein Interaction Partner: PRR20A, RBPMS, STUB1, UBC, HSPA1A, IKZF3, GATA3, RUNX1, RELA, NFATC1, HIST1H1B, HDAC1, KAT8, REL, IKZF4, NFAT5, NFATC2, HDAC4, HDAC2, HDAC7, KAT5, HDAC9,
Protein Size: 431

Molekulargewicht: 47 kDa

Gen-ID: 50943

NCBI Accession: NM_014009, NP_054728

UniProt: Q9BZS1

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation