TFAM Antikörper (N-Term)

Produktnummer ABIN2777277

Produktdetails anti-TFAM Antikörper

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Kaninchen, Rind (Kuh), Hund, Meerschweinchen, Schwein, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TFAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: AKTTELIRRI AQRWRELPDS KKKIYQDAYR AEWQVYKEEI SRFKEQLTPS

Homologie: Cow: 92%, Dog: 83%, Guinea Pig: 75%, Horse: 92%, Human: 100%, Mouse: 75%, Pig: 92%, Rabbit: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against Transcription Factor AntibodiesAM. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TFAM

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 246 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TFAM Antikörper (ABIN2777277)

Ogasawara, Liu, Pelicano, Hammoudi, Croce, Keating, Huang: "Alterations of mitochondrial biogenesis in chronic lymphocytic leukemia cells with loss of p53." in: Mitochondrion, Vol. 31, pp. 33-39, (2016) (PubMed).

Kemper, Stirone, Krause, Duckles, Procaccio: "Genomic and non-genomic regulation of PGC1 isoforms by estrogen to increase cerebral vascular mitochondrial biogenesis and reactive oxygen species protection." in: European journal of pharmacology, Vol. 723, pp. 322-9, (2014) (PubMed).

Vettor, Valerio, Ragni, Trevellin, Granzotto, Olivieri, Tedesco, Ruocco, Fossati, Fabris, Serra, Carruba, Nisoli: "Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism." in: American journal of physiology. Endocrinology and metabolism, Vol. 306, Issue 5, pp. E519-28, (2014) (PubMed).

Kemper, Zhao, Duckles, Krause: "Endogenous ovarian hormones affect mitochondrial efficiency in cerebral endothelium via distinct regulation of PGC-1 isoforms." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 33, Issue 1, pp. 122-8, (2013) (PubMed).

Teodoro, Duarte, Gomes, Varela, Peixoto, Rolo, Palmeira: "Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation." in: Mitochondrion, Vol. 13, Issue 6, pp. 637-46, (2013) (PubMed).

Miyazaki, Iwasawa, Nakashima, Mori, Shigemoto, Nakamura, Katagiri, Takayanagi, Tanaka: "Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption." in: The Journal of biological chemistry, Vol. 287, Issue 45, pp. 37808-23, (2012) (PubMed).

Lu, Chen, Zhang, Wang, Luo, Huang: "ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction." in: Cell death & disease, Vol. 3, pp. e422, (2012) (PubMed).

Walters, Wallace: "Urea cycle gene expression is suppressed by PFOA treatment in rats." in: Toxicology letters, Vol. 197, Issue 1, pp. 46-50, (2010) (PubMed).

Walters, Bjork, Wallace: "Perfluorooctanoic acid stimulated mitochondrial biogenesis and gene transcription in rats." in: Toxicology, Vol. 264, Issue 1-2, pp. 10-5, (2009) (PubMed).

Shi, Burkart, Nicoloro, Czech, Straubhaar, Corvera: "Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells." in: The Journal of biological chemistry, Vol. 283, Issue 45, pp. 30658-67, (2008) (PubMed).

Details zu TFAM

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Andere Bezeichnung: TFAM (TFAM Produkte)

Synonyme: tcf6 antikoerper, mttf1 antikoerper, mttfa antikoerper, tcf6l1 antikoerper, tcf6l2 antikoerper, tcf6l3 antikoerper, mttfa-A antikoerper, xl-mtTFA antikoerper, MGC153358 antikoerper, zgc:153358 antikoerper, MTTF1 antikoerper, MTTFA antikoerper, TCF6 antikoerper, TCF6L1 antikoerper, TCF6L2 antikoerper, TCF6L3 antikoerper, AI661103 antikoerper, Hmgts antikoerper, mtTFA antikoerper, tsHMG antikoerper, Mttfa antikoerper, transcription factor A, mitochondrial antikoerper, transcription factor A, mitochondrial L homeolog antikoerper, TFAM antikoerper, tfam.L antikoerper, tfam antikoerper, Tfam antikoerper

Hintergrund: The function remains unknown.This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.
Alias Symbols: TCF6, MtTF1, mtTFA, TCF6L1, TCF6L2, TCF6L3
Protein Interaction Partner: AGTRAP, FBXW11, ARL6IP1, NEDD1, PPP2R1A, GRSF1, UBC, MDM2, SUZ12, EED, PAN2, MYC, FN1, C1QBP, CAND1, COPS5, CUL3, ELAVL1, ICT1, TFB2M, TFB1M, PNP, NRF1,
Protein Size: 246

Molekulargewicht: 29 kDa

Gen-ID: 7019

NCBI Accession: NM_003201, NP_003192

UniProt: Q00059

Pathways: Chromatin Binding