MITF Antikörper (Middle Region)

Produktnummer ABIN2777228

Produktdetails anti-MITF Antikörper

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Rind (Kuh), Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MITF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NSNCEKEGFY KFEEQNRAES ECPGMNTHSR ASCMQMDDVI DDIISLESSY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MITF. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human MITF

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MITF Antikörper (ABIN2777228)

Schartl, Wilde, Laisney, Taniguchi, Takeda, Meierjohann: "A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies." in: The Journal of investigative dermatology, Vol. 130, Issue 1, pp. 249-58, (2009) (PubMed).

Details zu MITF

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Andere Bezeichnung: MITF (MITF Produkte)

Synonyme: MITF antikoerper, ws2a antikoerper, mitfa antikoerper, MITF-A antikoerper, LOC100313655 antikoerper, mitfb antikoerper, CMM8 antikoerper, MI antikoerper, WS2 antikoerper, WS2A antikoerper, bHLHe32 antikoerper, BCC2 antikoerper, Bhlhe32 antikoerper, Gsfbcc2 antikoerper, Vitiligo antikoerper, Wh antikoerper, bw antikoerper, mi antikoerper, vit antikoerper, MITF-H antikoerper, MITF-M antikoerper, CMI9 antikoerper, melanogenesis associated transcription factor antikoerper, microphthalmia-associated transcription factor antikoerper, microphthalmia-associated transcription factor S homeolog antikoerper, Microphthalmia antikoerper, MITF antikoerper, mitf antikoerper, LOC100313655 antikoerper, mitf.S antikoerper, LOC100534525 antikoerper, MICROP antikoerper, Mitf antikoerper

Hintergrund: MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: CMM8, MI, WS2, WS2A, bHLHe32
Protein Interaction Partner: EBP, STUB1, HK3, EPAS1, LEF1, APP, HINT1, ELAVL1, CDK2, SUMO2, PSMD14, MARK3, PIAS3, PIAS2, PIAS1, SUMO1, UBE2I, PAX3, OTX2, PAX6, PATZ1, GSK3B, TFEC, EP300, RPS6KA1, TFEB, MAPK14, TFE3, MAPK1, SPI1, FOS, CTNNB1, CDKN1A, RB1,
Protein Size: 357

Molekulargewicht: 39 kDa

Gen-ID: 4286

NCBI Accession: NM_198178, NP_937821

Pathways: Chromatin Binding