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PDZK1 Antikörper (N-Term)

PDZK1 Reaktivität: Human, Maus, Ratte, Pferd, Hund, Meerschweinchen, Kaninchen, Rind (Kuh) WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2776855
  • Target Alle PDZK1 Antikörper anzeigen
    PDZK1 (PDZ Domain Containing 1 (PDZK1))
    Bindungsspezifität
    • 12
    • 8
    • 7
    • 7
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    Human, Maus, Ratte, Pferd, Hund, Meerschweinchen, Kaninchen, Rind (Kuh)
    Wirt
    • 44
    • 7
    • 1
    • 1
    Kaninchen
    Klonalität
    • 46
    • 7
    Polyklonal
    Konjugat
    • 25
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PDZK1 Antikörper ist unkonjugiert
    Applikation
    • 49
    • 25
    • 18
    • 13
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    NSVTLLVLDG DSYEKAVKTR VDLKELGQSQ KEQGLSDNIL SPVMNGGVQT
    Homologie
    Cow: 92%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against PDZK1. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PDZK1
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    Discover our top product PDZK1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 519 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PDZK1 (PDZ Domain Containing 1 (PDZK1))
    Andere Bezeichnung
    PDZK1 (PDZK1 Produkte)
    Synonyme
    xpdzk1 antikoerper, PDZK1 antikoerper, CAP70 antikoerper, CLAMP antikoerper, NHERF-3 antikoerper, NHERF3 antikoerper, PDZD1 antikoerper, 1700023D20Rik antikoerper, 2610507N21Rik antikoerper, 4921513F16Rik antikoerper, AI267131 antikoerper, AI314638 antikoerper, AL022680 antikoerper, D3Ertd537e antikoerper, Pdzd1 antikoerper, mPDZK1 antikoerper, Clamp antikoerper, PDZ domain containing 1 antikoerper, PDZ domain containing 1 L homeolog antikoerper, PDZK1 antikoerper, pdzk1.L antikoerper, pdzk1 antikoerper, Pdzk1 antikoerper
    Hintergrund
    PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. PDZK1 may play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. PDZK1 may potentiate the CFTR chloride channel activity. It may function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. PDZK1 may be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
    Alias Symbols: CAP70, CLAMP, NHERF3, PDZD1, NHERF-3
    Protein Interaction Partner: AKT1, CDC37, Ptgir, ABCC4, CFTR, APP, Klhl17, Syngap1, Dlg4, SLC26A6, SLC22A4, SLCO1A2, SLC15A2, PDZK1IP1, SLC22A11, SLC22A12, AKAP10, SLC22A5, ABCC2, SCARB1, CLCN3, PEX5, ABCA1, SSTR5, SLC17A1, SLC9A3, GFAP, SLC34A3, FARP2, SLK, SLC9A3R1, SLC9A3R2, UBE2I
    Protein Size: 519
    Molekulargewicht
    57 kDa
    Gen-ID
    5174
    NCBI Accession
    NM_002614, NP_002605
    UniProt
    Q5T2W1
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