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Tropomyosin Antikörper (N-Term)

TPM1 Reaktivität: Human, Ratte, Maus, Zebrafisch (Danio rerio), Kaninchen, Rind (Kuh), Hund, Pferd, Schaf, Meerschweinchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2776783
  • Target Alle Tropomyosin (TPM1) Antikörper anzeigen
    Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))
    Bindungsspezifität
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 39
    • 31
    • 29
    • 12
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus, Zebrafisch (Danio rerio), Kaninchen, Rind (Kuh), Hund, Pferd, Schaf, Meerschweinchen
    Wirt
    • 40
    • 11
    Kaninchen
    Klonalität
    • 31
    • 20
    Polyklonal
    Konjugat
    • 27
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Tropomyosin Antikörper ist unkonjugiert
    Applikation
    • 25
    • 17
    • 9
    • 8
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    DRAEQAEADK KAAEDRSKQL EDELVSLQKK LKGTEDELDK YSEALKDAQE
    Homologie
    Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%, Zebrafish: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against TPM1. It was validated on Western Blot and immunohistochemistry.
    Aufreinigung
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human TPM1
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    Discover our top product TPM1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 284 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))
    Andere Bezeichnung
    TPM1 (TPM1 Produkte)
    Synonyme
    alpha-fTM antikoerper, Tm7 antikoerper, tpm1 antikoerper, MGC84844 antikoerper, AA986836 antikoerper, AI854628 antikoerper, TM2 antikoerper, Tm3 antikoerper, Tmpa antikoerper, Tpm-1 antikoerper, alpha-TM antikoerper, Alpha-tm antikoerper, Tma2 antikoerper, Tmsa antikoerper, TPM1 antikoerper, fb37a09 antikoerper, tm antikoerper, wu:fb37a09 antikoerper, CH1 antikoerper, alpha-tm antikoerper, alpha-tropomyosin antikoerper, C15orf13 antikoerper, CMD1Y antikoerper, CMH3 antikoerper, HTM-alpha antikoerper, TMSA antikoerper, TPMA antikoerper, Tm1 antikoerper, zgc:171719 antikoerper, zgc:55951 antikoerper, zgc:77009 antikoerper, tropomyosin 1 (alpha) antikoerper, tropomyosin antikoerper, tropomyosin 1 antikoerper, tropomyosin 1, alpha antikoerper, alpha-tropomyosin antikoerper, tropomyosin 1 L homeolog antikoerper, TPM1 antikoerper, tm7 antikoerper, Tpm1 antikoerper, tpma antikoerper, tpm1.L antikoerper, Smp_044010.2 antikoerper, LOC732984 antikoerper, tpm1 antikoerper
    Hintergrund
    TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction.This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
    Alias Symbols: CMH3, TMSA, TPM1-alpha, CMD1Y, C15orf13, HTM-alpha
    Protein Interaction Partner: GOLGA2, CAGE1, C1orf216, SYCE1, KXD1, TFPT, MAD1L1, TPM4, TP53, TNNT1, UBC, MDM2, ETFA, FOXK1, KIAA1598, PPP6R3, APPL2, CDC37, MGEA5, STUB1, ABI2, DNAJC7, HSP90B1, PARK2, LRCH3, PAN2, TGFBR1, SPTBN1, ATF2, MDC1, BRCA1, PPP4R2, SRXN1, NUDCD2, RBM15, THOC2,
    Protein Size: 284
    Molekulargewicht
    31 kDa
    Gen-ID
    7168
    NCBI Accession
    NM_000366, NP_000357
    UniProt
    P09493
    Pathways
    Regulation of Actin Filament Polymerization
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