UPF3B Antikörper (Middle Region)

Produktnummer ABIN2776615

Produktdetails anti-UPF3B Antikörper

Target: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UPF3B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KIDRIPERDK LKDEPKIKVH RFLLQAVNQK NLLKKPEKGD EKELDKREKA

Homologie: Dog: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against UPF3B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UPF3B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 483 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu UPF3B

Target: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Andere Bezeichnung: UPF3B (UPF3B Produkte)

Synonyme: HUPF3B antikoerper, MRXS14 antikoerper, RENT3B antikoerper, UPF3X antikoerper, 5730594O13Rik antikoerper, AI317193 antikoerper, AW541158 antikoerper, RGD1560264 antikoerper, UPF3B, regulator of nonsense mediated mRNA decay antikoerper, UPF3 regulator of nonsense transcripts homolog B (yeast) antikoerper, UPF3B antikoerper, Upf3b antikoerper

Hintergrund: UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
Alias Symbols: HUPF3B, MRXS14, RENT3B, UPF3X
Protein Interaction Partner: NCBP1, CIAO1, STAU1, UBC, UPF1, HECW2, RBM8A, UPF2, SMG1, EIF4A3, WIBG, WBP11, RNPS1, SART1, TOP2A, SNRPA1, NXF1, CAND1, COPS5, CUL5, USP21, EXOSC4, MCRS1, XRN1, TTC19, EIF6, UPF3B, HBB, UPF3A,
Protein Size: 483

Molekulargewicht: 58 kDa

Gen-ID: 65109

NCBI Accession: NM_080632, NP_542199

UniProt: Q9BZI7